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Molecular epidemiology and virulence characteristics of Staphylococcus aureus nasal colonization in medical

Xiaoying Xie1, Xinlu Dai1, Lijia Ni1

  • 1Department of Clinical Laboratory, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.

BMC Infectious Diseases
|March 14, 2018
PubMed
Abstract

Insights

Medical laboratory staff show high Staphylococcus aureus colonization rates, particularly in microbiological labs. Findings reveal key molecular characteristics and risk factors for S. aureus nasal carriage in this population.

Area of Science:

  • Microbiology
  • Epidemiology
  • Infectious Diseases

Background:

  • Medical laboratory staff have high Staphylococcus aureus (S. aureus) colonization risk due to pathogen exposure.
  • Limited data exists on S. aureus nasal colonization within this specific occupational group.

Purpose of the Study:

  • To determine the prevalence and molecular traits of S. aureus nasal colonization in Guangzhou medical laboratory personnel.
  • To compare S. aureus colonization between microbiological (MLS) and non-microbiological laboratory staff (NMLS).

Main Methods:

  • Nasal swab cultures from 434 medical laboratory staff (130 MLS, 304 NMLS) in Guangzhou.
  • Antimicrobial susceptibility testing, virulence gene detection, and molecular typing of S. aureus isolates.

Main Results:

  • Overall S. aureus carriage was 20.1%, higher in MLS (26.2%) than NMLS (17.4%).
  • Methicillin-resistant S. aureus (MRSA) prevalence was similar between groups; living with hospital staff was a risk factor.
  • Isolates from MLS showed reduced antibiotic resistance and increased virulence. Thirty-seven spa types were identified, with t338 (MSSA) and t437-SCCmec IV (MRSA) being predominant.

Conclusions:

  • This study offers insights into S. aureus nasal carriage risk factors, molecular epidemiology, and virulence in Guangzhou medical laboratory staff.
  • Findings highlight differences in S. aureus characteristics between MLS and NMLS, informing infection control strategies.
Keywords:
Antimicrobial susceptibilityMedical laboratoryNasal carriageStaphylococcus aureusVirulence genesspa type

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