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Updated: Feb 13, 2026
08:42
A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis
Published on: April 10, 2019
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[Relationship between vitamin D deficiency and necrotizing enterocolitis in preterm infants]
Ling-Rong Yang1, Hua Li, Tong Zhang
1Department of Pediatrics, Third People's Hospital of Chengdu/Second Affiliated Hospital of Chengdu, Chongqing Medical University, Chengdu 610031, China. 574303074@qq.com.
Summary
Low vitamin D levels in preterm infants and their mothers are linked to necrotizing enterocolitis (NEC). Maternal vitamin D supplementation may help prevent NEC in premature infants.
Area of Science:
- Neonatology
- Pediatric Gastroenterology
- Nutritional Science
Background:
- Necrotizing enterocolitis (NEC) is a severe gastrointestinal emergency in preterm infants.
- Vitamin D deficiency is increasingly recognized as a potential risk factor in neonatal conditions.
Purpose of the Study:
- To investigate the association between serum 25-hydroxyvitamin D (25-OHD) levels and the incidence of NEC in preterm infants.
- To explore the relationship between maternal and infant vitamin D levels in the context of NEC development.
Main Methods:
- A cohort of 429 preterm infants (<36 weeks gestation) and their mothers were studied.
- Serum 25-OHD levels were measured at admission for infants and mothers.
- Infants were categorized into NEC (n=22) and non-NEC (n=407) groups for comparison.
Main Results:
- Significantly lower serum 25-OHD levels were observed in both preterm infants and their mothers in the NEC group compared to the non-NEC group (P<0.001).
- Maternal and infant 25-OHD levels showed a positive correlation (P<0.001).
- Gestational age, birth weight, vitamin D status, and respiratory support duration were identified as risk factors for NEC.
Conclusions:
- Reduced serum 25-OHD levels in preterm infants and their mothers are associated with an increased risk of NEC.
- Vitamin D supplementation during pregnancy may be a crucial strategy for NEC prevention in premature neonates.
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