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Menopause

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...

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Menopause in CKD.

Kavitha Vellanki¹, Susan Hou²

¹Loyola University Medical Center, Maywood, IL; Edward Hines VA Hospital, Maywood, IL.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation

|March 14, 2018

Summary

This summary is machine-generated.

Menopause definition and management are complex in women with chronic kidney disease (CKD) stage 5D. Further research is needed to understand menopause

Keywords:

CKD-MBD Menopause anti-resorptive agents cardiovascular disease chronic kidney disease (CKD)dialysis early menopause female sex hormone replacement therapy (HRT)kidney transplant osteoporosis review sexual health vasomotor symptoms women’s health

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Area of Science:

Nephrology
Endocrinology
Women's Health

Background:

Most women with dialysis-dependent chronic kidney disease (CKD) stage 5 (CKD stage 5D) are postmenopausal.
Early menopause occurs across CKD stages 3-5D, complicating traditional definitions.
Hormone replacement therapy (HRT) for vasomotor symptoms lacks specific dosing studies in CKD populations.

Purpose of the Study:

To highlight the under-recognized challenges in managing menopause in CKD stage 5D patients.
To emphasize the need for research on menopause's impact on cardiovascular disease and osteoporosis risk in CKD.
To call for clinical trials to define menopause in CKD and evaluate HRT and osteoporosis treatments.

Main Methods:

Review of existing literature on menopause in CKD and kidney transplantation.
Identification of knowledge gaps in HRT and osteoporosis management for CKD patients.
Proposal for longitudinal clinical trials.

Main Results:

The traditional definition of menopause is inadequate for CKD stage 5D due to potential menses resumption with treatment.
Cardiovascular disease and osteoporosis risks associated with menopause are poorly understood in the context of CKD.
Current therapeutic options for menopause symptoms require specific testing in CKD and transplant populations.

Conclusions:

Menopause in CKD stage 5D is a neglected clinical problem requiring specific management guidelines.
CKD's influence on menopause transition and vice versa needs elucidation through dedicated research.
Efficacy and safety of standard menopause treatments must be validated in CKD and kidney transplantation cohorts.