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Plasma fibrinolytic activity in a group of hypogonadic men
Insights
Hypogonadal men and those with a history of deep venous thrombosis (DVT) show impaired fibrinolytic activity. This study highlights a common co-occurrence of defective fibrinolysis, hypogonadism, and DVT in men.
Area of Science:
- Endocrinology
- Hematology
- Vascular Biology
Background:
- Hypogonadism is associated with various health issues.
- Deep venous thrombosis (DVT) is a significant vascular condition.
- Fibrinolytic system function is crucial for preventing blood clots.
Purpose of the Study:
- To investigate fibrinolytic activity in hypogonadal men.
- To compare fibrinolysis in men with and without DVT antecedents.
- To explore the relationship between hypogonadism, fibrinolysis, and DVT.
Main Methods:
- Measured fibrinolytic activity using fibrin plate assay and tissue plasminogen activator antigen.
- Assessed venous occlusion response in hypogonadal men, men with DVT antecedents, and healthy controls.
- Identified low responders in fibrinolytic activity.
Main Results:
- Four hypogonadal men had a history of DVT.
- Abnormal fibrinolytic response to venous occlusion was observed in hypogonadal men with DVT antecedents.
- No significant difference in the prevalence of low fibrinolytic responders was found across groups.
Conclusions:
- The combination of defective fibrinolysis, hypogonadism, and DVT appears relatively common in men.
- A causal link between defective fibrinolysis and hypogonadism could not be established.
- Further research is needed to clarify the relationship between these conditions.
Abstract:
Fibrinolytic activity in response to venous occlusion (fibrin plate assay and tissue plasmogen activator antigen) was measured in 19 hypogonadic men (group 1), 23 non-hypogonadic men with deep venous thrombosis (DVT) antecedents and 20 healthy men (control group). Four hypogonadic men had DVT antecedents. Two of 20 controls were low responders against 6/19 and 6/23 in groups 1 and 2, respectively, (non-significant difference). The four hypogonadic men with DVT antecedent had abnormal response to venous occlusion. Whether defective fibrinolysis is causally related to hypogonadism cannot be established from these results but this study indicates that the combination of defective fibrinolysis, hypogonadism and DVT in man is relatively common.