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In Vitro Activity of Lefamulin against Sexually Transmitted Bacterial Pathogens

Susanne Paukner1, Astrid Gruss2, Jørgen Skov Jensen3

  • 1Nabriva Therapeutics GmbH, Vienna, Austria susanne.paukner@nabriva.com.

Antimicrobial Agents and Chemotherapy
|March 14, 2018
PubMed

Insights

Lefamulin shows strong in vitro activity against key bacteria causing sexually transmitted infections (STIs). This pleuromutilin antibiotic is a potential new treatment option, especially where resistance to current drugs is high.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Sexually transmitted infections (STIs) pose a significant global health challenge.
  • Rising antimicrobial resistance necessitates the development of novel therapeutic agents.
  • The pleuromutilin antibiotic class offers a potential avenue for new STI treatments.

Purpose of the Study:

  • To evaluate the in vitro activity of lefamulin against major bacterial pathogens responsible for STIs.
  • To assess lefamulin's efficacy against drug-susceptible and drug-resistant strains of Chlamydia trachomatis, Mycoplasma genitalium, and Neisseria gonorrhoeae.

Main Methods:

  • In vitro antimicrobial susceptibility testing was performed.
  • Minimum Inhibitory Concentrations (MIC50/90 and MIC range) were determined for lefamulin.
  • Standardized bacterial strains of Chlamydia trachomatis, Mycoplasma genitalium, and Neisseria gonorrhoeae were utilized.

Main Results:

  • Lefamulin exhibited potent in vitro activity against Chlamydia trachomatis (MIC50/90, 0.02/0.04 mg/liter).
  • Lefamulin demonstrated significant activity against Mycoplasma genitalium, including multidrug-resistant strains (MIC range, 0.002 to 0.063 mg/liter).
  • Lefamulin showed promising activity against both susceptible and resistant Neisseria gonorrhoeae (MIC50/90, 0.12/0.5 mg/liter).

Conclusions:

  • Lefamulin displays broad-spectrum in vitro activity against key bacterial STI pathogens.
  • Lefamulin represents a potential first-line antibiotic for STI treatment.
  • Its efficacy is particularly relevant for populations experiencing high rates of resistance to existing therapies.
Keywords:
Chlamydia trachomatisMycoplasma genitaliumNeisseria gonorrhoeaelefamulinpleuromutilinsexually transmitted diseasessexually transmitted infection

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