Brain Network Alterations in Alzheimer's Disease Identified by Early-Phase PIB-PET

The aim of this study was to identify the brain networks from early-phase ¹¹C-PIB (perfusion PIB, pPIB) data and to compare the brain networks of patients with differentiating Alzheimer's disease (AD) with cognitively normal subjects (CN) and of mild cognitively impaired patients (MCI) with CN. Forty participants (14 CN, 12 MCI, and 14 AD) underwent ¹¹C-PIB and ¹⁸F-FDG PET/CT scans. Parallel independent component analysis (pICA) was used to identify correlated brain networks from the ¹¹C-pPIB and ¹⁸F-FDG data, and a two-sample t-test was used to evaluate group differences in the corrected brain networks between AD and CN, and between MCI and CN. Our study identified a brain network of perfusion (early-phase ¹¹C-PIB) that highly correlated with a glucose metabolism (¹⁸F-FDG) brain network and colocalized with the default mode network (DMN) in an AD-specific neurodegenerative cohort. Particularly, decreased ¹⁸F-FDG uptake correlated with a decreased regional cerebral blood flow in the frontal, parietal, and temporal regions of the DMN. The group comparisons revealed similar spatial patterns of the brain networks derived from the ¹¹C-pPIB and ¹⁸F-FDG data. Our findings indicate that ¹¹C-pPIB derived from the early-phase ¹¹C-PIB could provide complementary information for ¹⁸F-FDG examination in AD.