Related Experiment Video
Updated: Feb 13, 2026

Author Spotlight: Exploring Glial Influence in Experience-Dependent Synaptic Pruning During Critical Periods
Published on: March 1, 2024
Proteolytic Remodeling of Perineuronal Nets: Effects on Synaptic Plasticity and Neuronal Population Dynamics
P. Lorenzo Bozzelli1,2, Seham Alaiyed3, Eunyoung Kim1
1Department of Neuroscience, Georgetown University Medical Center, 3800 Reservoir Rd NW, Washington, DC 20007, USA.
Abstract:
The perineuronal net (PNN) represents a lattice-like structure that is prominently expressed along the soma and proximal dendrites of parvalbumin- (PV-) positive interneurons in varied brain regions including the cortex and hippocampus. It is thus apposed to sites at which PV neurons receive synaptic input. Emerging evidence suggests that changes in PNN integrity may affect glutamatergic input to PV interneurons, a population that is critical for the expression of synchronous neuronal population discharges that occur with gamma oscillations and sharp-wave ripples. The present review is focused on the composition of PNNs, posttranslation modulation of PNN components by sulfation and proteolysis, PNN alterations in disease, and potential effects of PNN remodeling on neuronal plasticity at the single-cell and population level.
Related Concept Videos
Nucleosome Remodeling
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
Synaptic Signaling
Population Growth
Plasticity
Plasticizers
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
Plastic Behavior

