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Related Concept Videos

Amyloid Fibrils03:03

Amyloid Fibrils

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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Related Experiment Video

Updated: Feb 13, 2026

Correlative Light and Electron Microscopy to Study Microglial Interactions with β-Amyloid Plaques
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Direct Factor X sequestration by systemic amyloid light-chain amyloidosis.

Haruko Tashiro1, Ryosuke Shirasaki1, Masato Watanabe2

  • 1Department of Hematology/Oncology Teikyo University School of Medicine Itabashi-ku Tokyo Japan.

Clinical Case Reports
|March 14, 2018
PubMed
Summary

A patient with lymphoplasmacytic lymphoma and Factor X deficiency showed no increase in Factor X levels after treatment. Autopsy revealed Factor X co-localized with amyloid deposits in multiple organs.

Keywords:
Amyloid Light‐chain amyloidosisFactor X antibodyFactor X deficiencylymphoplasmacytic lymphoma

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Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Lymphoplasmacytic lymphoma is a rare B-cell malignancy.
  • Factor X deficiency is a rare bleeding disorder.
  • Co-occurrence of these conditions is exceptionally uncommon.

Observation:

  • A patient diagnosed with lymphoplasmacytic lymphoma presented with severe Factor X deficiency.
  • Standard treatments including fresh frozen plasma and anti-inhibitor coagulant complex were ineffective in raising Factor X levels.
  • The patient lacked any Factor X inhibitor, ruling out common causes for treatment non-response.

Findings:

  • Autopsy revealed extensive amyloid deposition across multiple organs.
  • Factor X was found to be deposited alongside amyloid in these organs.
  • This suggests a novel mechanism of Factor X sequestration by amyloidosis.

Implications:

  • This case highlights a potential link between amyloidosis and Factor X deficiency in lymphoplasmacytic lymphoma.
  • It suggests amyloid deposition can sequester coagulation factors, leading to functional deficiency.
  • Further research is warranted to explore this association and its clinical relevance.