Vertebral metastases from neuroendocrine tumours: How to avoid false positives on ⁶⁸Ga-DOTA-TOC PET using CT pattern...

To develop criteria to improve discrimination between vertebral metastases from neuroendocrine tumours (NETs) and benign bone lesions on PET combined with CT using DOTA-D-Phe¹-Tyr³-octreotide labelled with gallium-68 (⁶⁸Ga-DOTA-TOC).

In 535 NET patients, ⁶⁸Ga-DOTA-TOC PET/CT examinations were reviewed retrospectively for vertebral CT lesions and/or PET foci. For each vertebral PET abnormality, appearance on CT, biological volume (BV), standardized uptake value (SUV_max) and ratios to those of reference organs were determined. All vertebral abnormalities were characterized as a metastasis, a typical vertebral haemangioma (VH) or other benign lesion.

In 79 patients (14.8 %), we found 107 metastases, 34 VHs and 31 other benign lesions in the spine. The optimal cut-off values to differentiate metastases from benign lesions were BV ≥0.72 cm³, SUVmax ≥2, SUVmax ratio to a reference vertebra ≥2.1, to liver ≥0.28 and to spleen ≥0.14. They corresponded to lesion-based ⁶⁸Ga-DOTA-TOC PET/CT sensitivity of 87 %, 98 %, 97 %, 99 % and 94 %, and specificity of 55 %, 100 %, 90 %, 97 %, 100 %, respectively.

The high sensitivity of ⁶⁸Ga-DOTA-TOC-PET/CT in detecting NET vertebral metastases was confirmed; this study showed that specificity could be improved by combining CT features and quantifying ⁶⁸Ga-DOTA-TOC uptake.

• Bone metastases in neuroendocrine tumours correlate with prognosis. • Benign bone lesions may mimic metastases on ⁶⁸ Ga-DOTA-TOC PET/CT imaging. • The specific polka-dot CT pattern may be missing in some vertebral haemangiomas. • Lesion atypical for haemangiomas can be better characterized by quantifying ⁶⁸ Ga-DOTA-TOC uptake.