Related Experiment Video
Updated: Feb 13, 2026

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
Published on: September 13, 2018
Hippo-yap signaling in ocular development and disease
Matthew Lee1, Navneet Goraya1, Seonhee Kim1
1Shriners Hospitals Pediatric Research Center and Department of Anatomy and Cell Biology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania.
Abstract:
The Hippo-Yes associated protein (Yap) pathway plays an important role in organ size control by regulating cell proliferation, apoptosis, and stem cell renewal. Hippo-Yap signaling also functions at the level of cellular development in a variety of organs through its effects on cell cycle control, cell survival, cell polarity, and cell fate. Because of its important roles in normal development and homeostasis, abnormal regulation of this pathway has been shown to lead to pathological outcomes such as tissue overgrowth, tumor formation, and abnormal organogenesis, including ocular-specific disorders. In this review, we summarize how normal and perturbed control of Yap signaling is implicated in ocular development and disease Developmental Dynamics 247:794-806, 2018. © 2018 Wiley Periodicals, Inc.
Related Concept Videos
Endocrine Signaling
Bacterial Signaling
Yeast Signaling
What is Cell Signaling?
Paracrine Signaling
Synaptic Signaling

