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Cutaneous melanoma: From pathogenesis to therapy (Review)
Giulia C Leonardi1, Luca Falzone1, Rossella Salemi1
1Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.
International Journal of Oncology
|March 14, 2018
Summary
Melanoma treatment has advanced significantly due to targeted therapies like tyrosine kinase and immune checkpoint inhibitors. This review covers melanoma
Area of Science:
- Oncology
- Dermatology
- Immunology
Background:
- Melanoma treatment has been revolutionized by targeted therapies.
- Genomic alterations in MAPK and PI3K pathways drive melanoma development.
- Melanoma cells interact extensively with the tumor microenvironment and immune system.
Purpose of the Study:
- To review epidemiological features of cutaneous melanoma.
- To summarize biological mechanisms of melanoma development and progression.
- To discuss advanced stage melanoma treatment strategies and biomarkers.
Main Methods:
- Literature review of epidemiological data.
- Analysis of biological mechanisms in melanoma.
- Synthesis of current treatment strategies and biomarker evidence.
Main Results:
- Significant advancements in melanoma treatment within a decade.
- Identification of novel therapeutic targets based on pathway alterations and microenvironment interactions.
- Evidence supporting the use of predictive and prognostic biomarkers.
Conclusions:
- Understanding melanoma biology has led to revolutionary treatments.
- Current strategies focus on targeted therapies and immunotherapy.
- Biomarkers are crucial for personalized melanoma treatment.
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