Related Experiment Video
Updated: Feb 13, 2026

Failure of Cleaning Verification in Pharmaceutical Industry Due to Uncleanliness of Stainless Steel Surface
Published on: August 11, 2017
Analytical Methods for the Determination of Rosuvastatin in Pharmaceutical Formulations and Biological Fluids: A
Marilene Lopes Ângelo1, Fernanda de Lima Moreira2, André Luís Morais Ruela3
1a Faculty of Pharmaceutical Sciences, Federal University of Alfenas , Alfenas , Minas Gerais , Brazil.
Abstract:
Rosuvastatin calcium (ROS), ( Figure 1 ) belongs to the "statins" group, which is the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. This drug is indicated for dyslipidemias treatment and can help to decrease the level of "bad cholesterol" and can consequently reduce the development of atherosclerosis and the risk of heart diseases. ROS was developed by Astra-Zeneca and it was approved in 2003 by the FDA in the United States. In 2015, under the trade name Crestor®, it was the fourth largest selling drug in the United States with sales above $5 billion. This study presents a literature review of analytical methods for the quantification of ROS in pharmaceutical preparations and biological fluids. The major analytical methods described in this study for ROS were spectrophotometry, high-performance liquid chromatography (HPLC) coupled to ultraviolet (UV) detection, and tandem mass spectrometry (LC-MS/MS).
More Related Videos
05:07Characterizing Extracellular Vesicles from Biological Fluids
Published on: February 28, 2025
06:14Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients
Published on: October 15, 2017
Related Concept Videos
Development of Analytical Methods
Critical Numbers and the Closed Interval Method
Pharmaceutical Equivalents
Review and Preview
Percentiles are a type of fractile that partition data into...
Review and Preview
Biological Methods for Microbial Control