Related Experiment Video
Updated: Feb 13, 2026
05:00
A Modified Technique for Arteriovenous Fistula Construction in Rabbits
Published on: February 10, 2023
1.9K
The modified polymethyl methacrylate-silicone keratoprosthesis in rabbit model
1The Second Affiliated Hospital of Kunming Medical University, Kunming, China.
The International Journal of Artificial Organs
|March 14, 2018
Summary
This study shows a modified polymethyl methacrylate-silicone keratoprosthesis is safe and effective for alkali-burned rabbit eyes. Further research is needed to address elevated intraocular pressure complications.
Area of Science:
- Ophthalmology
- Biomaterials Science
- Surgical Innovation
Background:
- Alkali burns cause severe corneal damage, often requiring advanced reconstructive surgery.
- Current keratoprosthesis options have limitations in long-term efficacy and safety.
Purpose of the Study:
- To assess the safety and effectiveness of a novel polymethyl methacrylate-silicone keratoprosthesis.
- To evaluate a specialized surgical technique for implanting this artificial cornea in an alkali-burned rabbit model.
Main Methods:
- Seven alkali-burned rabbit corneas received polymethyl methacrylate-silicone keratoprostheses using autologous grafts.
- Long-term postoperative outcomes were monitored over a 16-month period.
Main Results:
- All implanted keratoprostheses remained transparent and in good position for 16 months, with no extrusion, infection, or endophthalmitis.
- Two cases experienced elevated intraocular pressure, and two developed temporary retroprosthetic membranes.
Conclusions:
- The modified polymethyl methacrylate-silicone keratoprosthesis and its surgical method offer a promising solution for alkali-burned eyes.
- Elevated intraocular pressure is identified as a key complication requiring further management strategies.
Related Concept Videos
00:57Modified Boxplots
11.3K
A standard box and whisker plot informs us about the spread of the data in a given sample. One can identify the minimum value, maximum value, first quartile value, second quartile or median value, and third quartile.
However, the box plot does not tell the reader about outliers - values that lie far from the center of the data. We can modify the standard box and whisker plot to identify the outliers and visualize the actual spread of the data in a sample.
Initially, we calculate the adjusted...
However, the box plot does not tell the reader about outliers - values that lie far from the center of the data. We can modify the standard box and whisker plot to identify the outliers and visualize the actual spread of the data in a sample.
Initially, we calculate the adjusted...
11.3K
01:19Antiasthma Drugs: Leukotriene Modifiers
1.9K
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
1.9K
01:30Modified-Release Drug Delivery Systems: Bioavailability
2
Modified-release (MR) dosage forms are designed to extend drug release over time, thereby maintaining stable plasma concentrations and reducing dosing frequency. However, their bioavailability is typically below 100% due to incomplete drug release and presystemic metabolism, and limitations in drug permeability across the gastrointestinal epithelium, all of which can restrict the fraction of the drug reaching systemic circulation. Consequently, studying the in vivo bioavailability of MR...
2
01:19Modified-Release Drug Delivery Systems: Overview
3
Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
3
01:23Modified-Release Drug Delivery Systems: Classification
2
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
2
01:24Modified-Release Drug Delivery Systems: Site-Targeted
4
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
4