Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Adult Stem Cells01:33

Adult Stem Cells

33.9K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
33.9K
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

3.4K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
3.4K
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

4.5K
A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
4.5K
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

2
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
2
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

2
Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
2
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.2K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long COVID risk by pre-infection symptoms and functional status: A retrospective cohort study of data from the All of Us Research Program.

PloS one·2026
Same author

Potential missed diagnostic opportunities after low dose CT screening for lung cancer: results from the National Lung Cancer Screening Trial.

Diagnosis (Berlin, Germany)·2026
Same author

Relation of Adverse Childhood Experiences to Clinical and Patient-Reported Outcomes for Adults With Sickle Cell Disease: A Registry Study.

Pediatric blood & cancer·2025
Same author

Chronic Health Conditions and Academic Achievement: A Childhood Cancer Survivor Study Report.

JCO oncology practice·2025
Same author

Long COVID risk by pre-infection symptoms and functional status: A retrospective cohort study of data from the <i>All of Us</i> Research Program.

medRxiv : the preprint server for health sciences·2025
Same author

Functional cognitive performance augments cognitive screening data in older adults.

Frontiers in aging neuroscience·2025

Related Experiment Video

Updated: Feb 13, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

20.5K

Mentoring Program for Young Adults with Sickle Cell Disease.

Christine Berg1, Allison King2, Dorothy Farrar Edwards3

  • 1a Program in Occupational Therapy , Washington University School of Medicine , St. Louis , Missouri , USA.

Occupational Therapy in Health Care
|March 14, 2018
PubMed
Summary

A short-term mentoring program for young adults with sickle cell disease (SCD) showed no significant goal improvement due to persistent health and social barriers. The study highlights challenges faced by young adults with SCD.

Keywords:
Sickle cell diseasementoringoccupational therapy

More Related Videos

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

10.4K
Community-based Adapted Tango Dancing for Individuals with Parkinson's Disease and Older Adults
09:19

Community-based Adapted Tango Dancing for Individuals with Parkinson's Disease and Older Adults

Published on: December 9, 2014

26.4K

Related Experiment Videos

Last Updated: Feb 13, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

20.5K
Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

10.4K
Community-based Adapted Tango Dancing for Individuals with Parkinson's Disease and Older Adults
09:19

Community-based Adapted Tango Dancing for Individuals with Parkinson's Disease and Older Adults

Published on: December 9, 2014

26.4K

Area of Science:

  • Medical Social Work
  • Adolescent Health
  • Hematology

Background:

  • Young adults with sickle cell disease (SCD) face unique challenges transitioning to adulthood.
  • Effective support programs are needed to address the complex health and social needs of this population.
  • Goal attainment scaling offers a framework for measuring progress in individualized support programs.

Purpose of the Study:

  • To describe a short-term mentoring program for young adults with SCD.
  • To evaluate the program's effectiveness using goal attainment scaling.
  • To identify barriers impacting goal achievement in this population.

Main Methods:

  • Descriptive case studies were used to document the program.
  • Two young adults with SCD participated in the mentoring program.
  • Goal attainment scaling was employed to measure progress.

Main Results:

  • Participants dropped out after limited engagement (3 and 7 visits).
  • No significant changes in goal attainment scores were observed.
  • Hospitalizations, pain episodes, and social determinants of health were identified as persistent barriers.

Conclusions:

  • The short-term mentoring program did not demonstrate effectiveness in improving goal attainment for young adults with SCD.
  • Complex, cumulative health and social barriers significantly impede progress for young adults with SCD.
  • Further research is needed to explore effective, long-term interventions addressing these multifaceted barriers.