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Predictive Prognostic Value of Tissue-Based MicroRNA Expression in Oral Squamous Cell Carcinoma: A Systematic Review
G Troiano1, F Mastrangelo1, V C A Caponio1
11 Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Journal of Dental Research
|March 14, 2018
Summary
MicroRNA (miRNA) expression levels can predict oral squamous cell carcinoma (OSCC) patient prognosis. Specific upregulated and downregulated miRNAs correlate with poor survival, aiding in treatment strategy selection.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Oral squamous cell carcinoma (OSCC) has a low survival rate due to recurrence and metastasis.
- Predicting OSCC tumor behavior is crucial for effective treatment strategies.
- MicroRNAs (miRNAs) are investigated as potential tissue biomarkers for prognosis.
Purpose of the Study:
- To systematically review and perform a meta-analysis on miRNA expression and OSCC patient survival.
- To evaluate the prognostic value of specific miRNA expression levels in OSCC.
Main Methods:
- Systematic literature search on MEDLINE/PubMed, SCOPUS, Web of Science, and Google Scholar.
- Quality assessment using the Newcastle-Ottawa Scale.
- Meta-analysis of 15 cohort studies (1,200 OSCC samples) comparing survival based on miRNA expression.
Main Results:
- Upregulation of 9 miRNAs (e.g., miR-21, miR-155-5p) correlated with poor prognosis.
- Downregulation of 7 miRNAs (e.g., miR-204, miR-101) also correlated with poor prognosis.
- Pooled hazard ratios indicated significant associations between miRNA expression and overall/disease-free survival (HRs: 2.65 and 1.95).
Conclusions:
- Specific miRNA expression levels are robust predictors of OSCC patient prognosis.
- miRNA biomarkers can inform treatment decisions for OSCC.
- Further research into miRNA roles in OSCC progression is warranted.
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