Prelimbic Cortex Deep Brain Stimulation Reduces Binge Size in a Chronic Binge Eating Rat Model
Can Sarica1,2, Mazhar Ozkan3, Husniye Hacioglu Bay3,2
1Department of Neurosurgery, Marmara University, Istanbul, Turkey.
Stereotactic and Functional Neurosurgery
|March 14, 2018
Summary
Low-frequency deep brain stimulation (DBS) of the prelimbic cortex effectively reduced binge eating in rats. This finding suggests a potential therapeutic approach for prefrontal cortex dysfunction linked to binge eating and addiction.
Area of Science:
- Neuroscience
- Behavioral Science
- Medical Research
Background:
- Binge eating (BE) is characterized by excessive food intake and loss of control, a core feature of eating disorders.
- Dysfunction in the mesocorticolimbic pathway is implicated in the pathophysiology of binge eating.
- Prefrontal cortex alterations are associated with binge eating and addiction.
Purpose of the Study:
- To investigate the efficacy of deep brain stimulation (DBS) in the prelimbic cortex for reducing binge eating.
- To test the hypothesis that DBS in the prelimbic cortex can decrease binge size in a rat model.
Main Methods:
- Rats were induced into a chronic binge eating state using a palatable diet.
- Deep brain stimulation (DBS) electrodes were implanted in the prelimbic cortex.
- Rats received sham, low-frequency (60 Hz), and high-frequency (130 Hz) stimulation, with binge size measured after each condition.
Main Results:
- Low-frequency (60 Hz) stimulation significantly reduced binge size compared to sham stimulation (p < 0.0001).
- High-frequency (130 Hz) stimulation showed no significant effect on binge size compared to sham (p = 0.9).
Conclusions:
- Low-frequency prelimbic cortex stimulation may be a viable strategy for treating binge eating.
- This approach could address prefrontal cortex hypofunction associated with binge eating and addiction.
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