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Antibody-Based Agents in the Management of Antibiotic-Resistant Staphylococcus aureus Diseases

Pietro Speziale1,2, Simonetta Rindi3, Giampiero Pietrocola4

  • 1Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy. pspeziale@unipv.it.

Microorganisms
|March 14, 2018
PubMed

Insights

Antibiotic-resistant Staphylococcus aureus infections necessitate new treatments. This review explores antibody-based therapies, including monoclonal antibodies, for passive immunization against S. aureus.

Area of Science:

  • Microbiology
  • Immunology
  • Infectious Diseases

Background:

  • Staphylococcus aureus is a significant human pathogen causing diverse infections.
  • Antibiotic resistance in S. aureus strains limits treatment options.
  • Alternative therapies are needed due to widespread antibiotic resistance.

Purpose of the Study:

  • To review the development of antibody-based agents against S. aureus.
  • To assess the therapeutic potential of monoclonal antibodies for passive immunization.
  • To update on strategies for treating and preventing S. aureus infections.

Main Methods:

  • Literature review of current research on anti-S. aureus antibodies.
  • Analysis of studies on monoclonal antibody development for S. aureus.
  • Evaluation of passive immunization strategies.

Main Results:

  • Antibody-based therapies are a promising alternative to antibiotics.
  • Monoclonal antibodies show potential for targeted treatment and prevention.
  • Despite controversy, antibodies offer significant host protection against S. aureus.

Conclusions:

  • Antibody-based agents, particularly monoclonal antibodies, represent a viable therapeutic avenue.
  • Passive immunization with antibodies can aid in managing S. aureus infections.
  • Further development is crucial for effective antibody-based treatments against resistant strains.
Keywords:
Staphylococcus aureusantibodiespassive immunizationvirulence factors

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