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CD99: A Cell Surface Protein with an Oncojanus Role in Tumors

Maria Cristina Manara1, Michela Pasello2, Katia Scotlandi3

  • 1Laboratory of Experimental Oncology, CRS Development of Biomolecular Therapies, Rizzoli Orthopaedic Institute, 40136 Bologna, Italy. mariacristina.manara@ior.it.

Genes
|March 14, 2018
PubMed

Insights

The cell surface molecule CD99 has a dual role in cell behavior, acting as both a malignancy promoter and an oncosuppressor in tumors. Understanding its isoforms and expression is key for therapeutic targeting.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cancer Research

Background:

  • CD99 is a cell surface molecule involved in immune and tumor cell differentiation, adhesion, and migration.
  • CD99 exhibits a dual role, promoting malignancy in some tumors while acting as an oncosuppressor in others.
  • The CD99 gene produces two opposing isoforms within the same cell.

Purpose of the Study:

  • To review key studies on the dual role of CD99 and its isoforms.
  • To discuss challenges and strategies related to CD99 research and therapeutic targeting.
  • To identify new research avenues for CD99 and its signaling pathways.

Main Methods:

  • Literature review of key studies on CD99.
  • Analysis of CD99's dual role in different cell types and tumors.
  • Discussion of therapeutic potential and future research directions.

Main Results:

  • CD99's function is context-dependent, acting as either an oncogene or oncosuppressor.
  • Two isoforms of CD99 exist with opposing intracellular functions.
  • CD99 presents an attractive, yet complex, therapeutic target.

Conclusions:

  • Further elucidation of CD99's spatial and temporal expression is crucial.
  • Understanding CD99's dual role is essential for developing effective cancer therapies.
  • Targeting CD99 offers potential for novel therapeutic strategies in oncology.
Keywords:
CD99antibodiestargeted therapiestumor progression

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