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Updated: Feb 13, 2026

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
Published on: October 9, 2014
Alternative Splicing in the Hippo Pathway-Implications for Disease and Potential Therapeutic Targets
Sean Porazinski1, Michael Ladomery2
1Faculty of Health and Applied Sciences, University of the West of England, Frenchay Campus, Bristol BS16 1QY, UK. Sean.Porazinski@uwe.ac.uk.
Abstract:
Alternative splicing is a well-studied gene regulatory mechanism that produces biological diversity by allowing the production of multiple protein isoforms from a single gene. An involvement of alternative splicing in the key biological signalling Hippo pathway is emerging and offers new therapeutic avenues. This review discusses examples of alternative splicing in the Hippo pathway, how deregulation of these processes may contribute to disease and whether these processes offer new potential therapeutic targets.
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