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Burden of cardiovascular risk factors and cardiovascular disease in childhood cancer survivors: data from the German CVSS-study

  • 0Department of Pediatric Hematology/Oncology/Hemostaseology, Center for Pediatric and Adolescent Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.
European Heart Journal +

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March 14, 2018

|

March 14, 2018

View abstract on PubMed

Summary

This summary is machine-generated.

Childhood cancer survivors face a significantly higher risk of premature cardiovascular disease (CVD) and risk factors like hypertension and dyslipidemia. This increased burden necessitates long-term monitoring and management for these young adults.

Area Of Science

  • Cardiology
  • Oncology
  • Epidemiology

Background

  • Childhood cancer survivors (CCS) face long-term health challenges.
  • Cardiovascular sequelae are a significant concern in this population.
  • Quantifying cardiovascular risk factors and disease in CCS is crucial for management.

Purpose Of The Study

  • To assess the prevalence of cardiovascular risk factors (CVRF) and cardiovascular disease (CVD) in German childhood cancer survivors (CCS).
  • To compare CVRF and CVD prevalence in CCS to general population cohorts.
  • To identify premature cardiovascular risks in long-term survivors of childhood cancer.

Main Methods

  • Prospective cardiovascular screening of 1002 CCS (aged 23-48) using standardized clinical and laboratory assessments.
  • Comparison of CVRF and CVD prevalence with three German population-based cohorts (Gutenberg Health Study and others).
  • Log-binomial regression models used to determine relative risks and rate advancement periods for CVRF and CVD.

Main Results

  • CCS showed increased risk for arterial hypertension (RR 1.38) and dyslipidemia (RR 1.26), indicating premature onset by 6-8 years.
  • No significant differences in obesity or diabetes prevalence were observed compared to the general population.
  • Overt CVD was found in 4.5% of CCS, with congestive heart failure and venous thromboembolism being most frequent; prevalence increased with age.

Conclusions

  • Long-term childhood cancer survivors exhibit a considerably increased risk for premature cardiovascular disease compared to the general population.
  • These findings highlight a substantial burden of cardiovascular morbidity and mortality in adult survivors of childhood cancer.
  • Early and continuous cardiovascular screening is essential for managing long-term health risks in this population.

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