Related Experiment Video
Updated: Feb 13, 2026

Primary Neuronal Cultures from the Brains of Late Stage Drosophila Pupae
Published on: May 28, 2007
Late-Stage Functionalization of Drug-Like Molecules Using Diversinates
Christian A Kuttruff1, Margit Haile1, Johannes Kraml1
1Department for Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co KG, Birkendorfer Straße 65, 88397, Biberach an der Riss, Germany.
Abstract:
Late-stage functionalization (LSF) is a powerful method to quickly generate new analogues of a lead structure without resorting to de novo synthesis. We have leveraged Baran Diversinates to carry out late-stage functionalizations on lead structures from internal drug discovery projects and accurately predicted regioselectivities using computational methods. Our functionalization successfully afforded specific regioisomers which were in line with our predictions. To enhance reactivity, decrease reaction time, and increase reaction yields, we have developed new functionalization conditions involving iron(III) catalysis. Finally, we demonstrate how our LSF reactions using Baran Diversinates can lead to new analogues with improved in vitro DMPK parameters.
Related Concept Videos
Cell Adhesion Molecules - Types and Functions
CAM Families
The Integrin family of proteins is primarily involved...
Molecules and Compounds
Stages of Infection
Positive Regulator Molecules
Functional Groups
Stages of Sleep
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...

