Related Experiment Video
Updated: Feb 13, 2026

Constructing a Low-budget Laser Axotomy System to Study Axon Regeneration in C. elegans
Published on: November 15, 2011
Integrin Activation: Implications for Axon Regeneration
Menghon Cheah1,2, Melissa R Andrews3
1John van Geest Centre for Brain Repair, University of Cambridge, Cambridge CB2 0PY, UK. mc747@cam.ac.uk.
Abstract:
Integrin activation is essential for creating functional transmembrane receptors capable of inducing downstream cellular effects such as cell migration, cell spreading, neurite outgrowth and axon regeneration. Integrins are bidirectional signalling molecules that mediate their effects by 'inside-out' and 'outside-in' signalling. This review will provide a detailed overview of integrin activation focusing on intracellular activation in neurons and discussing direct implications in the regulation of neurite outgrowth and axon regeneration.
Related Concept Videos
Activation of Integrins
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding...
Integrins
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...
Neurons: The Axon
The axon attaches to the cell body at a cone-shaped elevation called the axon hillock. The initial part of the axon, closest to the hillock, is known as the initial segment....
Whole Body Regeneration
Liver Regeneration
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Overview of Regeneration and Repair
Regeneration
All animals have varying degrees of...

