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Use of Human Perivascular Stem Cells for Bone Regeneration
Published on: May 25, 2012
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Applications of Metals for Bone Regeneration
Kristina Glenske1, Phil Donkiewicz2, Alexander Köwitsch3
1Clinic of Small Animals, c/o Institute of Veterinary Anatomy, Histology and Embryology, Justus Liebig University of Giessen, D-35392 Giessen, Germany. Kristina.Glenske@vetmed.uni-giessen.de.
International Journal of Molecular Sciences
|March 15, 2018
Summary
Calcium phosphate bone substitutes guide regeneration, but optimal material properties for new bone formation and resorption remain elusive. This review examines the role of metals in enhancing bone regeneration materials.
Area of Science:
- Biomaterials Science
- Dental Medicine
- Tissue Engineering
Background:
- Bone regeneration is crucial in dental medicine, utilizing calcium phosphate (CaP)-based substitutes like natural grafts and synthetic alloplastics.
- Optimal bone substitutes must support bone ingrowth and resorb appropriately for complete healing (restitutio ad integrum).
- Existing CaP materials influence regenerative processes, but the ideal balance between new bone formation and material degradation is not yet achieved.
Purpose of the Study:
- To review the effects of frequently used metals as integral components in materials designed for bone regeneration.
- To provide an overview of current knowledge regarding how metals influence bone healing and regeneration processes.
Main Methods:
- Literature review focusing on calcium phosphate (CaP)-based bone substitutes and their interaction with regenerative processes.
- Analysis of studies investigating the addition of substances like collagen, growth factors, and cells to bone regeneration materials.
- Examination of research on the incorporation and effects of metals and metal ions in bone regeneration materials.
Main Results:
- Calcium phosphate materials significantly influence osteoblast growth, differentiation, and osteoclastic resorption.
- Previous attempts to enhance CaP materials with collagen, growth factors, or cells have not yielded sufficient or prompt applications.
- Metals and metal ions are integral to bone tissue and play functional roles in cellular environments and bone healing.
Conclusions:
- The precise material characteristics for balancing new bone formation and degradation in bone substitutes are still under investigation.
- Metals are increasingly recognized for their potential to enhance bone regeneration materials.
- Further research is needed to fully understand and optimize the role of metals in bone regeneration therapies.
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