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Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
Published on: April 26, 2024
Delayed sleep phase syndrome and bipolar disorder: Pathogenesis and available common biomarkers
Farid Talih1, Nour Y Gebara2, Farah S Andary2
1Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon; Department of Psychiatry, American University of Beirut Medical Center, Beirut, Lebanon.
Abstract:
Circadian rhythm disturbances are common in bipolar affective disorder (BD). Delayed sleep-wake phase syndrome (DSWPD) is the most prevalent circadian rhythm sleep-wake disorder (CRSWDs) and is frequently observed in BD. It is unclear whether DSWPD in BD is an independent process or is a consequence of BD. In this hypothetical review, we discuss the overlap between BD and DSWPD and potential common biomarkers for DSWPD and BD. The review will include a discussion of the genetics of DSWPD and BD. Biomarkers elucidating the pathophysiological processes occurring in these two disorders may offer insight into the etiology and prognosis of both conditions.
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