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Updated: Feb 13, 2026
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Corticospinal Excitability Modulation During Action Observation
Published on: December 31, 2013
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Corticospinal Excitability Is Modulated as a Function of Postural Perturbation Predictability.
Kimiya Fujio1,2, Hiroki Obata3, Taku Kitamura2
1Department of Rehabilitation Science, Faculty of Health Care Science, Chiba Prefectural University of Health Sciences, Chiba, Japan.
Frontiers in Human Neuroscience
|March 15, 2018
Summary
Human standing balance relies on predictive control. This study shows corticospinal excitability in the tibialis anterior (TA) muscle anticipates expected postural perturbations, especially with timing cues.
Area of Science:
- Neuroscience
- Human Motor Control
- Systems Neuroscience
Background:
- Corticospinal pathway is crucial for feedback control of human standing.
- Corticospinal excitability adapts to posture.
- Involvement in predictive control of standing is unclear.
Purpose of the Study:
- Investigate anticipatory modulation of corticospinal excitability.
- Examine soleus (SOL) and tibialis anterior (TA) muscles.
- Determine role in predictive standing balance control.
Main Methods:
- Transcranial magnetic stimulation (TMS) to induce motor-evoked potentials (MEPs).
- Measured MEPs at six stimulus intensities under three conditions: No perturbation, No Cue, and Cue.
- Analyzed stimulus-response curves and used ANOVA.
Main Results:
- TA muscle MEPs enhanced when perturbation was expected, particularly with timing cues.
- Corticospinal excitability modulation was more apparent with timing information.
- SOL muscle MEPs showed no modulation but slight reduction with timing cues.
Conclusions:
- Predicting future standing balance states modulates corticospinal excitability in TA.
- Timing information enhances this predictive modulation.
- Corticospinal pathway involved in both predictive and feedback control of posture.
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