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Mechanisms of Tolerance Induction by Dendritic Cells In Vivo

Hitoshi Hasegawa1, Takuya Matsumoto1

  • 1Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Japan.

Frontiers in Immunology
|March 15, 2018
PubMed

Dendritic cells (DCs) are a heterogeneous population playing a pivotal role in immune responses and tolerance. DCs promote immune tolerance by participating in the negative selection of autoreactive T cells in the thymus. Furthermore, to eliminate autoreactive T cells that have escaped thymic deletion, DCs also induce immune tolerance in the periphery through various mechanisms. Breakdown of these functions leads to autoimmune diseases. Moreover, DCs play a critical role in maintenance of homeostasis in body organs, especially the skin and intestine. In this review, we focus on recent developments in our understanding of the mechanisms of tolerance induction by DCs in the body.

Keywords:
dendritic cellsdevelopmentimmune toleranceintestineregulatory T cellsskinthymus

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