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Prevalence Rates of ADIPOQ Polymorphisms in Indian Population and a Comparison with Other Populations
Sandhya Kiran Pemmasani1,2, Rasika Raman1, Anuradha Acharya2
1Genetics Department, Mapmygenome India Limited, Hyderabad, Telangana, India.
Prevalence of adiponectin (ADIPOQ) gene polymorphisms in Indians differs significantly from East Asians, Africans, and Admixture Americans. Europeans show similar ADIPOQ polymorphism patterns to Indians.
Area of Science:
- Genetics and genomics
- Population genetics
- Molecular biology
Background:
- The adiponectin gene (ADIPOQ) encodes a hormone crucial for insulin sensitization, fat metabolism, immunity, and inflammation.
- ADIPOQ gene polymorphisms are linked to lower adiponectin levels, increasing risks for diabetes and cardiovascular diseases.
Purpose of the Study:
- To determine the prevalence of ADIPOQ gene polymorphisms in the Indian population.
- To compare these prevalence rates with those in other global populations.
Main Methods:
- Utilized microarray-based genotypic data from 703 Indian individuals.
- Analyzed 14 ADIPOQ polymorphisms using frequency estimation, identity-by-descent, Hardy-Weinberg equilibrium, and Chi-square tests.
Main Results:
- Calculated allelic and genotypic frequencies for ADIPOQ polymorphisms in the Indian cohort.
- Performed Chi-square tests to compare frequencies across diverse global populations.
Conclusions:
- Indian population exhibits distinct ADIPOQ allelic and genotypic frequencies compared to East Asians, Admixture Americans, and Africans.
- European populations share similar genotypic and allelic patterns of ADIPOQ polymorphisms with Indians.
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