Related Experiment Video

Updated: Feb 13, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

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Expression Profiles of Genes-Potential Therapy Targets-and Their Relationship to Survival in Renal Cell Carcinoma

N V Apanovich1, M V Peters2, P V Apanovich1

  • 1Research Centre for Medical Genetics, Моscow, 115478, Russia.

Doklady. Biochemistry and Biophysics
|March 15, 2018
PubMed

Insights

Clear cell renal cell carcinoma (CCRCC) pathogenesis involves PI3K-AKT-mTOR and Ras-RAF-ERK pathways. Gene expression differences in these pathways correlate with patient survival and VEGFA levels.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Clear cell renal cell carcinoma (CCRCC) pathogenesis is primarily driven by the PI3K-AKT-mTOR and Ras-RAF-ERK signaling pathways.
  • Targeted therapies for CCRCC focus on inhibiting key genes and proteins within these critical pathways.

Purpose of the Study:

  • To investigate the expression and coexpression levels of target genes within the PI3K-AKT-mTOR and Ras-RAF-ERK pathways in CCRCC.
  • To analyze differences in pathway gene function between CCRCC patients with varying lifespans (above and below 3.5 years).
  • To determine the relationship between VEGFA gene expression and patient survival duration.

Main Methods:

  • Gene expression and coexpression analysis.
  • Comparative analysis of signaling pathway gene function based on patient survival data.
  • Correlation analysis between VEGFA expression and lifespan.

Main Results:

  • Identified differences in the functioning of genes within one of the major signaling pathways in tumors from CCRCC patients with different lifespans.
  • Revealed a correlation between the expression level of the VEGFA gene and patient survival duration.

Conclusions:

  • The study highlights the differential roles of signaling pathway genes in CCRCC progression and patient outcomes.
  • VEGFA expression is a potential prognostic biomarker for clear cell renal cell carcinoma survival.

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