Related Experiment Video

Updated: Feb 13, 2026

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

9.5K

VEGF-R1 as a Potential Molecular Target for Anticancer Therapy

E G Tyrsina1, S I Nikulitskiy2, A N Inshakov2

  • 1Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation, Moscow, 115478, Russia. tyrsina@yandex.ru.

Doklady. Biochemistry and Biophysics
|March 15, 2018
PubMed

Insights

Vascular Endothelial Growth Factor Receptor 1 (VEGF-R1) is present in tumor cell nuclei, not normal cells. Its expression level correlates with tumor malignancy, supporting its use as a target for novel cancer therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • The Vascular Endothelial Growth Factor Receptor 1 (VEGF-R1) plays a role in tumor angiogenesis and progression.
  • Targeted therapies aim to inhibit specific molecules driving cancer growth.

Purpose of the Study:

  • To investigate the potential of VEGF-R1 as a molecular target for oncology.
  • To determine the localization and prognostic significance of VEGF-R1 in tumor cells.

Main Methods:

  • Developed a novel method for measuring protein content in intact cell nuclei.
  • Quantified VEGF-R1 expression in the nuclei of tumor and normal cells.

Main Results:

  • VEGF-R1 was detected in the nuclei of tumor cells exclusively, not in normal cells.
  • A direct correlation was established between nuclear VEGF-R1 expression levels and the degree of tumor cell malignancy.
  • This correlation suggests prognostic value for nuclear VEGF-R1 levels.

Conclusions:

  • VEGF-R1 is a promising molecular target for anticancer therapy.
  • Nuclear expression of VEGF-R1 serves as a potential biomarker for tumor malignancy and prognosis.
  • Further research into inhibiting VEGF-R1 activity is warranted for therapeutic development.

More Related Videos

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent06:54

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent

Published on: September 3, 2013

11.8K
Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy12:03

Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy

Published on: September 5, 2016

8.3K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.0K
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.7K
Molecular Models02:00

Molecular Models

Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
43.9K
Molecular Shape and Polarity03:37

Molecular Shape and Polarity

Dipole Moment of a Molecule
76.0K
Potential Energy00:52

Potential Energy

The energy stored by a structure and location of matter in space is called potential energy. For instance, raising a kettlebell changes its spatial location and increases its potential energy. Similarly, a stretched rubber band contains potential energy which, under certain conditions, can be converted into other forms of energy, such as kinetic energy.
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
42.9K
Molecular Orbital Theory II03:51

Molecular Orbital Theory II

Molecular Orbital Energy Diagrams
27.7K