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Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
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Infectious myocarditis: the role of the cardiac vasculature

Linde Woudstra1,2, Lynda J M Juffermans3,4,5, Albert C van Rossum3,4,5

  • 1Department of Pathology, VU University Medical Center, (room 0E46), De Boelelaan 1117, 1081, HV, Amsterdam, The Netherlands. l.woudstra@vumc.nl.

Heart Failure Reviews
|March 15, 2018
PubMed

Insights

Infectious myocarditis involves the heart's immune response to infection. This review details how cardiac blood vessels, targeted by microbes, influence myocarditis development and severity.

Area of Science:

  • Cardiology
  • Immunology
  • Pathology

Background:

  • Infectious myocarditis stems from an immune response to microbial heart infections.
  • The heart's blood vessels are crucial in the disease's development.

Purpose of the Study:

  • To review the role of cardiac (micro)vasculature in infectious myocarditis pathogenesis.
  • To highlight the impact of vascular dysfunction on myocardial health.

Main Methods:

  • Literature review focusing on the cardiac vasculature in infectious myocarditis.
  • Analysis of endothelial cell infection, immune cell interactions, and vascular dysfunction.

Main Results:

  • Cardiac endothelial cells are direct targets of microbial infection.
  • Vascular adhesion and antigen-presenting molecules modulate immune responses.
  • Vascular damage leads to thrombus formation, vasospasm, and impaired cardiac perfusion.

Conclusions:

  • The cardiac vasculature is central to infectious myocarditis pathogenesis.
  • Vascular dysfunction contributes to severe outcomes like myocardial infarction.
  • Understanding vascular roles can inform therapeutic strategies for infectious myocarditis.

Keywords:
Endothelial cellsInfectionMyocardial infarctionMyocarditisVasculature

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