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Updated: Feb 13, 2026

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
Metabolomics: A High-Throughput Platform for Metabolite Profile Exploration.
Jing Cheng1, Wenxian Lan2, Guangyong Zheng3
1Department of Medical Instrument, Shanghai University of Medicine and Health Sciences, Shanghai, China.
Metabolomics measures small molecules in biological samples to understand disease mechanisms and identify biomarkers. This review covers the entire metabolomics pipeline, from design to interpretation, for a systems-level view of metabolism.
Area of Science:
- Metabolomics and systems biology
Background:
- Metabolomics quantifies small-molecule metabolites in biological samples (fluids, tissues, breath).
- It reveals metabolic responses to stimuli and genetic changes, offering insights into disease mechanisms and biomarkers.
- Metabolomics complements genomics and transcriptomics, bridging genotype and phenotype.
Purpose of the Study:
- To review the complete metabolomics study pipeline.
- To aid understanding of metabolic effects and functions at a systems level.
Main Methods:
- Experimental design and sample collection/preparation.
- Sample detection techniques.
- Data analysis and mechanism interpretation.
Main Results:
- Metabolomics provides systematic insights into disease mechanisms.
- It offers potential biomarkers for various diseases.
- Recent technological advancements accelerate metabolomics research.
Conclusions:
- Metabolomics is a powerful tool for understanding biological systems.
- A comprehensive understanding of the metabolomics pipeline is crucial for effective application.
- This review facilitates the interpretation of metabolic effects and metabolite functions.
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