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Apolipoprotein B and platelet function in diabetes mellitus.

P Kubisz, M Parizek, S Cronberg

    Haemostasis
    |January 1, 1986
    PubMed
    Summary

    Patients with insulin-dependent diabetes exhibit elevated apolipoprotein B levels and increased platelet hyperreactivity, suggesting a link between these factors and cardiovascular disease risk.

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    Area of Science:

    • Cardiology
    • Endocrinology
    • Hematology

    Background:

    • Insulin-dependent diabetes mellitus is associated with cardiovascular complications.
    • Platelet activation and aggregation play a crucial role in atherogenesis.

    Purpose of the Study:

    • To investigate serum apolipoprotein B levels and platelet function in patients with insulin-dependent diabetes.
    • To explore the relationship between apolipoprotein B and platelet hyperreactivity in diabetes.

    Main Methods:

    • Measured serum apolipoprotein B levels in 32 diabetic patients and 34 healthy controls.
    • Assessed platelet aggregation induced by adenosine diphosphate and adrenaline.
    • Quantified circulating platelet aggregates, plasma beta-thromboglobulin, and platelet factor 4.
    • Measured malondialdehyde production by platelets in the presence of N-ethyl maleimide.

    Main Results:

    • Diabetic patients had significantly higher serum apolipoprotein B levels (1.51 g/l vs. 1.18 g/l).
    • Diabetic platelets showed enhanced aggregation responses to adenosine diphosphate and adrenaline.
    • Increased circulating platelet aggregates, elevated beta-thromboglobulin and platelet factor 4 were observed in diabetics.
    • Diabetic platelets produced more malondialdehyde, indicating increased oxidative stress.

    Conclusions:

    • Insulin-dependent diabetes is characterized by elevated apolipoprotein B and platelet hyperreactivity.
    • The findings suggest a potential link between high apolipoprotein B and platelet dysfunction in diabetes.
    • Further research is warranted to understand the implications for atherogenesis.

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