Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Enzymatic adaptations consequent to long-term strength training.

P A Tesch, P V Komi, K Häkkinen

    International Journal of Sports Medicine
    |March 1, 1987
    PubMed
    Summary

    Six months of strength training led to muscle fiber growth but decreased key enzyme activities involved in energy production. Detraining reversed these changes in one group, suggesting adaptations are reversible.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Velocity-based resistance training: do women need greater velocity loss to maximize adaptations?

    European journal of applied physiology·2022
    Same author

    Reply to Egginton et al.: The utility of the Muscle2View pipeline to quantify the capillary-to-muscle fiber interface.

    Journal of applied physiology (Bethesda, Md. : 1985)·2020
    Same author

    Active recovery shows favorable IGF-I and IGF binding protein responses following heavy resistance exercise compared to passive recovery.

    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society·2019
    Same author

    Effects of morning vs. evening combined strength and endurance training on physical performance, sleep and well-being.

    Chronobiology international·2019
    Same author

    Substantial fat mass loss reduces low-grade inflammation and induces positive alteration in cardiometabolic factors in normal-weight individuals.

    Scientific reports·2019
    Same author

    Autophagy is induced by resistance exercise in young men, but unfolded protein response is induced regardless of age.

    Acta physiologica (Oxford, England)·2018

    Area of Science:

    • Exercise physiology
    • Muscle biochemistry
    • Sports science

    Background:

    • Strength training influences muscle adaptations, including fiber size and enzymatic activity.
    • Understanding the metabolic consequences of different training types and detraining is crucial for optimizing performance and recovery.

    Purpose of the Study:

    • To investigate the impact of heavy-resistance (HR) and explosive strength (EX) training on muscle enzyme activities.
    • To examine the effects of subsequent detraining on these enzymatic adaptations.
    • To correlate changes in muscle fiber area with specific enzyme activity alterations.

    Main Methods:

    • 21 physically active men underwent 6 months of either HR or EX training.
    • Muscle biopsies from m. vastus lateralis were analyzed for enzyme activities (HK, ATPase, CS, PFK, LDH, MK, CK).

    Related Experiment Videos

  • Activities were measured using fluorometrical assays on freeze-dried tissue.

    • Main Results:

    • Both HR and EX training increased fast-twitch (FT) fiber area, with HR showing a significant increase in mean fiber area.
    • Detraining led to a return to pretraining fiber size in the EX group.
    • Activities of hexokinase (HK) and creatine kinase (CK) decreased post-training, and most enzymes (except LDH) showed reduced activity when both groups were combined post-detraining.

    Conclusions:

    • Strength training-induced muscle hypertrophy is associated with a decrease in certain enzyme activities crucial for ATP regeneration.
    • The observed enzymatic changes suggest a shift in metabolic pathways rather than an enhancement of phosphagen, glycolytic, or oxidative metabolism.
    • Detraining can reverse some of the observed muscle adaptations, highlighting the plasticity of muscle metabolism.