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Behavioral Disturbances: An Innovative Approach to Monitor the Modulatory Effects of a Nutraceutical Diet
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Inhibition of mTOR/S6K1/4E-BP1 Signaling by Nutraceutical SIRT1 Modulators

Sara Bianchi1, Luca Giovannini1

  • 1a Department of Translational Research and New Technologies in Medicine and Surgery , Pharmacology, Medical School, University of Pisa , Pisa , Italy.

Nutrition and Cancer
|March 15, 2018
PubMed

Insights

Nutraceuticals like berberine and quercetin modulate the mTOR pathway, crucial in diseases. Combinations showed synergistic effects, highlighting their therapeutic potential in regulating mTOR signaling.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Nutraceutical Science

Background:

  • The mechanistic target of rapamycin (mTOR) pathway is implicated in numerous human diseases due to its hyperactivity.
  • Inhibitors of the mTOR pathway are potential therapeutic agents.
  • Sirtuin 1 (SIRT1) and AMP-activated protein kinase (AMPK) are key regulators of the mTOR pathway.

Purpose of the Study:

  • To investigate the effects of berberine, quercetin, tyrosol, and ferulic acid on the mTOR/S6K1/4E-BP1 signaling pathway.
  • To explore potential synergistic effects of specific combinations: berberine + tyrosol, tyrosol + ferulic acid, and ferulic acid + quercetin.

Main Methods:

  • Evaluation of the impact of individual nutraceuticals and their combinations on the mTOR/S6K1/4E-BP1 signaling cascade.
  • Analysis of the interplay between mTOR, SIRT1, and AMPK pathways.

Main Results:

  • Berberine, quercetin, tyrosol, and ferulic acid demonstrated a significant relationship with the mTOR/S6K1/4E-BP1 pathway.
  • Synergistic effects were observed in specific tested combinations of these compounds.
  • The study confirmed the intricate regulation of mTOR by SIRT1 and AMPK.

Conclusions:

  • The tested nutraceuticals directly influence the mTOR/S6K1/4E-BP1 signaling pathway.
  • Combinations of berberine, tyrosol, and ferulic acid exhibit synergistic effects, suggesting enhanced therapeutic potential.
  • Reciprocal regulation between mTOR, SIRT1, and AMPK pathways is critical and modulated by these nutraceuticals.

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