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Between-occasion repeatability of fractional exhaled nitric oxide measurements in children

Kamil Barański1, Jan E Zejda1

  • 1. Department of Epidemiology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.

Jornal Brasileiro De Pneumologia : Publicacao Oficial Da Sociedade Brasileira De Pneumologia E Tisilogia
|March 15, 2018
PubMed

Insights

Fractional exhaled nitric oxide (FENO) measurements are reproducible in children aged 6-9 years for respiratory health surveys. This study confirms short-term repeatability for epidemiological research.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Epidemiology
  • Biomarker Measurement

Background:

  • Fractional exhaled nitric oxide (FENO) is a non-invasive biomarker for airway inflammation.
  • Assessing FENO repeatability is crucial for reliable epidemiological studies in children.
  • Understanding FENO variability in different pediatric respiratory groups is important.

Purpose of the Study:

  • To evaluate the short-term repeatability of fractional exhaled nitric oxide (FENO) measurements.
  • To assess FENO repeatability in children aged 6 to 9 years within an epidemiological survey.
  • To determine if FENO measurements are reproducible across asymptomatic, symptomatic, and asthma groups.

Main Methods:

  • 101 children (6-9 years) underwent two FENO measurements one week apart.
  • Participants were categorized into asymptomatic, symptomatic, and asthma groups.
  • Repeatability was assessed using absolute/relative differences and concordance correlation coefficients.

Main Results:

  • FENO measurements demonstrated strong correlation (0.98) between the two sessions.
  • No significant difference was found in intragroup FENO measurements (p = 0.2).
  • Intergroup comparisons of FENO measurements showed significant differences.

Conclusions:

  • FENO measurements exhibit good short-term reproducibility in children within epidemiological settings.
  • FENO can be reliably used as a biomarker in pediatric respiratory epidemiological surveys.
  • Further research may explore intergroup differences in FENO levels and their clinical significance.

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