Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Extracellular Matrix01:42

The Extracellular Matrix

89.5K
Overview
89.5K
The Sense of Self: Reflected Self-Appraisal and Social Comparison02:57

The Sense of Self: Reflected Self-Appraisal and Social Comparison

56.2K
According to Charles Cooley, we base our image on what we think other people see (Cooley 1902). We imagine how we must appear to others, then react to this speculation. We don certain clothes, prepare our hair in a particular manner, wear makeup, use cologne, and the like—all with the notion that our presentation of ourselves is going to affect how others perceive us. We expect a certain reaction, and, if lucky, we get the one we desire and feel good about it. But more than that, Cooley...
56.2K
Rigid Body Equilibrium Problems - I00:49

Rigid Body Equilibrium Problems - I

5.5K
A rigid body is said to be in static equilibrium when the net force and the net torque acting on the system is equal to zero. To solve for rigid body equilibrium problems, do the following steps.
5.5K
Rigid Body Equilibrium Problems - II01:21

Rigid Body Equilibrium Problems - II

8.1K
A rigid body is in static equilibrium when the net force and the net torque acting on the system are equal to zero.
Consider two children sitting on a seesaw, which has negligible mass. The first child has a mass (m1) of 26 kg and sits at point A, which is 1.6 meters (r1) from the pivot point B; the second child has a mass (m2) of 32 kg and sits at point C. How far from the pivot point B should the second child sit (r2) to balance the seesaw?
8.1K
Introduction to Special Senses01:26

Introduction to Special Senses

7.7K
Sensory receptors play an integral part in comprehending our external and internal environments. They receive diverse stimuli, converting them into the nervous system's electrochemical signals. This conversion occurs as the stimulus alters the sensory neuron's cell membrane potential, instigating the generation of an action potential. This action potential is subsequently transmitted to the central nervous system (CNS), which integrates with other sensory data or higher cognitive...
7.7K
Angular Momentum: Rigid Body01:11

Angular Momentum: Rigid Body

15.9K
The total angular momentum of a rigid body can be calculated using the summation of the angular momentum of all the tiny particles rotating in the same plane. Considering all the tiny particles rotating in the x-y plane, the direction of angular momentum of all such particles and that of the rigid body would be perpendicular to the plane of the rotation along the z-axis.
This calculation can get complicated when tiny particles within the rigid body are not rotating in the same plane but have...
15.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Challenges and prospects for malaria elimination in the Greater Mekong Subregion.

Acta tropica·2011
Same author

[Optimization of extraction procedure of tongmai granules by orthogonal design with pharmacodynamic index].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2011
Same author

Determinants of postoperative corneal edema and impact on goldmann intraocular pressure.

Cornea·2011
Same author

Z-palatopharyngoplasty plus genioglossus advancement and hyoid suspension for obstructive sleep apnea hypopnea syndrome.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2011
Same author

Efficient and selective photodimerization of 2-naphthalenecarbonitrile mediated by cucurbit[8]uril in an aqueous solution.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology·2011
Same author

Quality assurance and quality improvement in U.S. clinical molecular genetic laboratories.

Current protocols in human genetics·2011

Related Experiment Video

Updated: Feb 13, 2026

Quantification and Size-profiling of Extracellular Vesicles Using Tunable Resistive Pulse Sensing
12:01

Quantification and Size-profiling of Extracellular Vesicles Using Tunable Resistive Pulse Sensing

Published on: October 19, 2014

19.8K

Standard Loading Profile in Matrix Rigidity Sensing.

Chenling Dong1, Xiaofeng Chen1, Bin Chen2

  • 1Department of Engineering Mechanics, Zhejiang University, Hangzhou, People's Republic of China.

Biophysical Journal
|March 15, 2018
PubMed
Summary

Cells sense matrix rigidity using a contractile unit, revealing a consistent loading velocity and step size linked to actin filament monomers. This suggests the contractile unit regulates force application for accurate rigidity sensing.

More Related Videos

Standardized SDS-PAGE Workflow for Personalized Protein Corona Profiling in Early Cancer Detection
10:02

Standardized SDS-PAGE Workflow for Personalized Protein Corona Profiling in Early Cancer Detection

Published on: December 19, 2025

502
Longitudinal Measurement of Extracellular Matrix Rigidity in 3D Tumor Models Using Particle-tracking Microrheology
11:11

Longitudinal Measurement of Extracellular Matrix Rigidity in 3D Tumor Models Using Particle-tracking Microrheology

Published on: June 10, 2014

12.1K

Related Experiment Videos

Last Updated: Feb 13, 2026

Quantification and Size-profiling of Extracellular Vesicles Using Tunable Resistive Pulse Sensing
12:01

Quantification and Size-profiling of Extracellular Vesicles Using Tunable Resistive Pulse Sensing

Published on: October 19, 2014

19.8K
Standardized SDS-PAGE Workflow for Personalized Protein Corona Profiling in Early Cancer Detection
10:02

Standardized SDS-PAGE Workflow for Personalized Protein Corona Profiling in Early Cancer Detection

Published on: December 19, 2025

502
Longitudinal Measurement of Extracellular Matrix Rigidity in 3D Tumor Models Using Particle-tracking Microrheology
11:11

Longitudinal Measurement of Extracellular Matrix Rigidity in 3D Tumor Models Using Particle-tracking Microrheology

Published on: June 10, 2014

12.1K

Area of Science:

  • Cellular mechanobiology
  • Biophysics
  • Materials science

Background:

  • Cellular functions are influenced by mechanical forces and matrix rigidity.
  • Understanding force application during matrix rigidity sensing is crucial for mechanosensing protein function.

Purpose of the Study:

  • Investigate the force application features of a cellular contractile unit during matrix rigidity sensing.
  • Determine if matrix rigidity is sensed with fixed parameters.
  • Correlate sensing parameters with cellular components.

Main Methods:

  • Analysis of a contractile unit model on matrices.
  • Investigating displacement, loading velocity, and force application during rigidity sensing.

Main Results:

  • Matrix rigidity is sensed with a fixed step size in displacement.
  • A fixed apparent loading velocity is observed during rigidity sensing.
  • The fixed step size correlates with the monomer size of actin filaments.

Conclusions:

  • The loading profile during matrix rigidity sensing is regulated by the contractile unit.
  • The contractile unit acts as a standard for sensing varying matrix rigidity.
  • Actin filament monomer size influences the displacement step size in rigidity sensing.