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Related Experiment Video

Updated: Feb 13, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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Neutrophil Defects as Risk Factors for Periodontal Diseases.

Thomas C Hart, Lior Shapira, Thomas E Van Dyke

    Journal of Periodontology
    |March 15, 2018
    PubMed
    Summary

    Neutrophil dysfunction, both inherited and acquired, is a significant risk factor for periodontal diseases. Further prospective studies are needed to confirm this association in periodontitis.

    Keywords:
    Periodontitis/etiologyneutrophilsperiodontitis/microbiologyrisk factors

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    Area of Science:

    • Oral biology
    • Immunology
    • Periodontology

    Background:

    • Periodontal diseases arise from complex interactions between bacteria and host response.
    • Existing hypotheses suggest equal susceptibility or varying bacterial virulence as primary drivers.
    • Neutrophil function is critical in combating oral pathogens.

    Purpose of the Study:

    • To review and analyze the role of neutrophil dysfunction as a risk factor for periodontitis.
    • To examine intrinsic and acquired neutrophil abnormalities in the context of periodontal disease etiology.

    Main Methods:

    • Literature review of existing studies on neutrophil function and periodontal diseases.
    • Analysis of intrinsic (genetic) and acquired (induced) neutrophil abnormalities.
    • Evaluation of the evidence implicating neutrophil dysfunction in periodontitis onset.

    Main Results:

    • A substantial body of evidence suggests neutrophil dysfunction is a significant risk factor for periodontal diseases.
    • Both intrinsic genetic defects and acquired abnormalities (bacterial or extrinsic) in neutrophils are implicated.
    • The reviewed data strongly suggests a link between impaired neutrophil function and periodontitis.

    Conclusions:

    • Neutrophil dysfunction is a key factor in the etiology of periodontal diseases.
    • Further prospective, longitudinal epidemiological studies are necessary to definitively establish the association.
    • Understanding neutrophil roles can refine strategies for preventing and managing periodontitis.