Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Systematic Error: Methodological and Sampling Errors01:15

Systematic Error: Methodological and Sampling Errors

11.1K
In the case of systematic errors, the sources can be identified, and the errors can be subsequently minimized by addressing these sources. According to the source, systematic errors can be divided into sampling, instrumental, methodological, and personal errors.
Sampling errors originate from improper sampling methods or the wrong sample population. These errors can be minimized by refining the sampling strategy. Defective instruments or faulty calibrations are the sources of instrumental...
11.1K
Fundamental Attribution Error01:14

Fundamental Attribution Error

13.8K
According to some social psychologists, people tend to overemphasize internal factors as explanations—or attributions—for the behavior of other people. They tend to assume that the behavior of another person is a trait of that person, and to underestimate the power of the situation on the behavior of others. They tend to fail to recognize when the behavior of another is due to situational variables, and thus to the person’s state. This erroneous assumption is...
13.8K
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

9.7K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
9.7K
Random Error01:04

Random Error

9.8K
Random or indeterminate errors originate from various uncontrollable variables, such as variations in environmental conditions, instrument imperfections, or the inherent variability of the phenomena being measured. Usually, these errors cannot be predicted, estimated, or characterized because their direction and magnitude often vary in magnitude and direction even during consecutive measurements. As a result, they are difficult to eliminate. However, the aggregate effect of these errors can be...
9.8K
Margin of Error01:27

Margin of Error

7.7K
The margin of error is also called the maximum error of an estimate. The margin of error is the maximum possible or expected difference between the observed sample parameter value and the actual population parameter value. For proportion, it is the maximum difference between the value of sample proportion obtained from the data and the true value of population proportion. As the true value of the population parameter is not known, the margin of error is calculated using the sample statistic.
7.7K
Standard Error of the Mean01:13

Standard Error of the Mean

12.5K
The sampling variability of a statistic is defined as how much the statistic varies from one sample to another. The sampling variability of a statistic is typically measured by measuring its standard error.
The standard error of the mean is an example of a standard error. It is a unique standard deviation known as the standard deviation of the sampling distribution of the mean. The standard error of the mean is a statistic that calculates how correctly a sample distribution represents a...
12.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Capillary electrophoresis for the screening and diagnosis of inherited hemoglobin disorders. Ready for prime time?

Clinical chemistry and laboratory medicine·2015
Same author

Screening Tests for Cushing's Syndrome: Urinary Free Cortisol Role Measured by LC-MS/MS.

The Journal of clinical endocrinology and metabolism·2015
Same author

Microarray-based IgE detection in tears of patients with vernal keratoconjunctivitis.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2015
Same author

Fetal Endothelial Remodeling in Late-Onset Gestational Hypertension.

American journal of hypertension·2015
Same author

Calcimimetic and vitamin D analog use in hemodialyzed patients is associated with increased levels of vitamin K dependent proteins.

Endocrine·2015
Same author

Synergistic antitumour activity of RAF265 and ZSTK474 on human TT medullary thyroid cancer cells.

Journal of cellular and molecular medicine·2015
Same journal

Accuracy of emergency physicians' probability estimates for acute coronary syndrome.

Diagnosis (Berlin, Germany)·2026
Same journal

Interfering factors in the normative diagnostic approach.

Diagnosis (Berlin, Germany)·2026
Same journal

Using generative AI to support clinical reasoning coaching: a theory-informed approach.

Diagnosis (Berlin, Germany)·2026
Same journal

Learning from what went right: a Safety-II application of the SIDER protocol to a case of occult breast cancer.

Diagnosis (Berlin, Germany)·2026
Same journal

Impact of clinical reasoning and diagnostic error education for nurses.

Diagnosis (Berlin, Germany)·2026
Same journal

Progress in mast cell activation syndrome: the global consensus-2 diagnostic criteria at six years.

Diagnosis (Berlin, Germany)·2026
See all related articles

Related Experiment Video

Updated: Feb 13, 2026

Remote Laboratory Management: Respiratory Virus Diagnostics
14:56

Remote Laboratory Management: Respiratory Virus Diagnostics

Published on: April 6, 2019

33.7K

Laboratory-associated and diagnostic errors: a neglected link.

Mario Plebani1

  • 11Department of Laboratory Medicine, University-Hospital of Padova, 35128 Padova, Italy.

Diagnosis (Berlin, Germany)
|March 16, 2018
PubMed
Summary
This summary is machine-generated.

Diagnostic errors in clinical laboratories persist, especially in pre- and post-analytical phases. Improving patient safety requires addressing the entire laboratory testing cycle through enhanced collaboration.

Keywords:
brain-to-brain loopdiagnostic errorslaboratory medicinelaboratory-associated errorspatient safetyquality

More Related Videos

Virtual Reality Tools for Assessing Unilateral Spatial Neglect: A Novel Opportunity for Data Collection
07:04

Virtual Reality Tools for Assessing Unilateral Spatial Neglect: A Novel Opportunity for Data Collection

Published on: March 10, 2021

4.6K
Using Micro-Electro-Mechanical Systems MEMS to Develop Diagnostic Tools
16:05

Using Micro-Electro-Mechanical Systems MEMS to Develop Diagnostic Tools

Published on: October 1, 2007

8.0K

Related Experiment Videos

Last Updated: Feb 13, 2026

Remote Laboratory Management: Respiratory Virus Diagnostics
14:56

Remote Laboratory Management: Respiratory Virus Diagnostics

Published on: April 6, 2019

33.7K
Virtual Reality Tools for Assessing Unilateral Spatial Neglect: A Novel Opportunity for Data Collection
07:04

Virtual Reality Tools for Assessing Unilateral Spatial Neglect: A Novel Opportunity for Data Collection

Published on: March 10, 2021

4.6K
Using Micro-Electro-Mechanical Systems MEMS to Develop Diagnostic Tools
16:05

Using Micro-Electro-Mechanical Systems MEMS to Develop Diagnostic Tools

Published on: October 1, 2007

8.0K

Area of Science:

  • Clinical Laboratory Science
  • Patient Safety
  • Diagnostic Accuracy

Background:

  • Clinical laboratories are crucial for patient care, but diagnostic errors remain a significant concern.
  • While analytical performance has improved, pre- and post-analytical errors are still prevalent.
  • The 'brain-to-brain laboratory loop' concept highlights the importance of extra-analytical phases for quality.

Purpose of the Study:

  • To emphasize the critical role of extra-analytical phases in laboratory quality.
  • To advocate for a holistic approach to laboratory testing, encompassing all phases.
  • To reduce total error rates and enhance patient safety.

Main Methods:

  • Review of the 'brain-to-brain laboratory loop' concept.
  • Analysis of error sources in pre-analytical, analytical, and post-analytical phases.
  • Examination of data from various clinical settings on diagnostic errors.

Main Results:

  • Diagnostic errors are frequently linked to laboratory testing, particularly in pre- and post-analytical steps.
  • Errors often stem from inappropriate test requests, result interpretation, and utilization.
  • Both laboratory professionals and non-laboratory operators contribute to errors.

Conclusions:

  • Improving patient safety necessitates a comprehensive assessment and enhancement of all laboratory testing phases.
  • Effective collaboration between laboratory professionals, clinicians, and nurses is essential.
  • Addressing extra-analytical factors is key to reducing diagnostic errors and improving patient outcomes.