Related Experiment Video
Updated: Feb 13, 2026
07:13
Orienteering as a Tool for Cognitive Research: An Implementation Guide
Published on: November 29, 2024
1.5K
Is self-guided internet-based cognitive behavioural therapy (iCBT) harmful? An individual participant data
Eirini Karyotaki1, Lise Kemmeren2, Heleen Riper1
1Department of Clinical Psychology,VU Amsterdam and Institute for Public Health Research,Amsterdam,the Netherlands.
Psychological Medicine
|March 16, 2018
Summary
Self-guided internet-based cognitive behaviour therapy (iCBT) shows lower symptom worsening rates than control conditions. This finding supports iCBT as a safe initial treatment for adult depression.
Area of Science:
- Mental Health Research
- Digital Therapeutics
- Clinical Psychology
Background:
- Safety concerns regarding self-guided internet-based cognitive behaviour therapy (iCBT) hinder its clinical adoption.
- Limited data exists on symptom deterioration rates associated with self-guided iCBT.
Purpose of the Study:
- To determine the prevalence of clinically significant deterioration in adults with depressive symptoms undergoing self-guided iCBT.
- To compare deterioration rates between self-guided iCBT and control conditions using an individual participant data meta-analysis.
Main Methods:
- An individual participant data (IPD) meta-analysis was conducted.
- Included were randomized controlled trials comparing self-guided iCBT to control conditions in adults with depression symptoms.
- Mixed effects models were used to analyze deterioration rates.
Main Results:
- Data from 3805 participants across 13 trials were analyzed.
- Overall, 7.2% of participants experienced clinically significant deterioration.
- Participants receiving self-guided iCBT were less likely to deteriorate compared to control groups (OR 0.62, p < 0.001).
Conclusions:
- Self-guided iCBT demonstrates a lower incidence of negative symptom outcomes compared to control conditions.
- iCBT can be considered a viable first-step treatment for adult depression.
- It offers a safe alternative to watchful waiting in primary care settings.
More Related Videos
06:26Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI
Published on: November 27, 2019
77.8K
11:38High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC
Published on: May 10, 2016
12.8K
Related Concept Videos
01:25Cognitive Therapy
1.3K
Cognitive therapy, pioneered by Aaron T. Beck in the 1960s, is a structured approach to addressing psychological distress by focusing on the influence of thoughts on emotions and behaviors. All cognitive therapies involve the basic assumption that human beings have control over their feelings, and that how individuals feel about something depends on how they think about it. Unlike psychoanalytic methods that delve into unconscious processes or humanistic approaches emphasizing...
1.3K
01:25Beck's Cognitive Therapy
408
Cognitive therapy is a psychological approach designed to address distortions in thinking, which can lead to negative emotions and unrealistic beliefs. These cognitive distortions often influence how individuals interpret and respond to situations, exacerbating emotional distress. Below are some prevalent cognitive distortions, their characteristics, and examples of how they manifest in thought processes.
Arbitrary Inference
Arbitrary inference involves making conclusions without sufficient...
Arbitrary Inference
Arbitrary inference involves making conclusions without sufficient...
408
01:38Cognitive Dissonance
37.5K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
37.5K
01:12Analysis of Population Pharmacokinetic Data
815
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
815
01:30Impact of Individuals on Individuals
403
Human behavior is intricately shaped by social influences that arise from interactions with others in diverse contexts. These influences not only mold beliefs and attitudes but also drive the regulation of behaviors through both direct communication and observational learning. The study of these processes falls within the domain of social psychology, which seeks to understand how individuals are affected by and affect those around them.Mechanisms of Social InfluenceDirect social influence...
403
01:09Directing Effect of Substituents: meta-Directing Groups
6.0K
Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
6.0K