Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Negative Regulator Molecules01:23

Negative Regulator Molecules

38.6K
Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.6K
Synaptic Signaling01:12

Synaptic Signaling

79.8K
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
79.8K
Regulated Protein Degradation02:58

Regulated Protein Degradation

8.9K
It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
8.9K
Plasticity00:58

Plasticity

3.1K
Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
3.1K
Plasticizers01:31

Plasticizers

378
Water-reducers, or plasticizers, are chemical admixtures used in concrete to improve strength and workability. These additives reduce the water-cement ratio without compromising workability, lower the cement content while maintaining the same workability, or increase workability to assist concrete placement in inaccessible areas.
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
378
Enteric Nervous System: Regulation of GI Motor Activity01:11

Enteric Nervous System: Regulation of GI Motor Activity

1.9K
The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting MAPK-dependent pathways to modulate reactive astrocyte pathology in neurodegeneration.

Communications biology·2026
Same author

Adissp activates insulin-independent glucose disposal and energy expenditure in white fat to treat diabetes and cardiometabolic disease.

Science advances·2026
Same author

Mutually exclusive alternative pre-mRNA splicing promotes adaptive metabolic stress signaling by JNK.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Cyclic GMP-AMP synthase deficiency predisposes the liver to alcohol-induced cell death and ER stress.

Hepatology communications·2026
Same author

Attack of the kinases: JNK signaling in metabolism.

American journal of physiology. Regulatory, integrative and comparative physiology·2026
Same author

Global loss of selenocysteine lyase in mice drives lipid accumulation in brown adipocytes.

American journal of physiology. Endocrinology and metabolism·2025

Related Experiment Video

Updated: Feb 13, 2026

3D Modeling of Dendritic Spines with Synaptic Plasticity
07:13

3D Modeling of Dendritic Spines with Synaptic Plasticity

Published on: May 18, 2020

7.4K

JIP1-Mediated JNK Activation Negatively Regulates Synaptic Plasticity and Spatial Memory.

Caroline Morel1,2, Tessi Sherrin3, Norman J Kennedy1,2

  • 1Howard Hughes Medical Institute.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|March 16, 2018
PubMed
Summary

JNK activation via JIP1 scaffold protein negatively regulates synaptic plasticity and memory. Blocking JIP1-JNK signaling enhances NMDA receptor function and improves hippocampus-dependent learning in mice.

Keywords:
JIP1JNKLTPfearmemoryplasticity

More Related Videos

Assessing Spatial Learning and Memory in Small Squamate Reptiles
08:44

Assessing Spatial Learning and Memory in Small Squamate Reptiles

Published on: January 3, 2017

8.0K
The Spatial Memory Game: Testing the Relationship Between Spatial Language, Object Knowledge, and Spatial Cognition
05:15

The Spatial Memory Game: Testing the Relationship Between Spatial Language, Object Knowledge, and Spatial Cognition

Published on: February 19, 2018

11.4K

Related Experiment Videos

Last Updated: Feb 13, 2026

3D Modeling of Dendritic Spines with Synaptic Plasticity
07:13

3D Modeling of Dendritic Spines with Synaptic Plasticity

Published on: May 18, 2020

7.4K
Assessing Spatial Learning and Memory in Small Squamate Reptiles
08:44

Assessing Spatial Learning and Memory in Small Squamate Reptiles

Published on: January 3, 2017

8.0K
The Spatial Memory Game: Testing the Relationship Between Spatial Language, Object Knowledge, and Spatial Cognition
05:15

The Spatial Memory Game: Testing the Relationship Between Spatial Language, Object Knowledge, and Spatial Cognition

Published on: February 19, 2018

11.4K

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • The c-Jun N-terminal kinase (JNK) pathway is crucial for learning and memory processes.
  • JNK-interacting protein 1 (JIP1) is a scaffold protein that mediates JNK activation.

Purpose of the Study:

  • To investigate the role of JIP1-mediated JNK activation in synaptic plasticity and hippocampus-dependent learning.
  • To determine how JIP1-JNK signaling influences NMDA receptor function.

Main Methods:

  • Comparison of wild-type mice with JIP1 mutant mice exhibiting impaired JIP1-mediated JNK activation.
  • Electrophysiological recordings to measure NMDAR currents and long-term potentiation (LTP) threshold.
  • Behavioral tests assessing hippocampus-dependent spatial memory and fear conditioning.

Main Results:

  • JIP1 mutant mice showed increased NMDAR currents and gene expression.
  • A lower threshold for LTP induction was observed in JIP1 mutant mice.
  • Mutant mice exhibited enhanced spatial memory and fear conditioning.

Conclusions:

  • JIP1-mediated JNK activation negatively regulates NMDAR-dependent synaptic plasticity.
  • This pathway acts as a constraint on hippocampus-dependent learning and memory.
  • JIP1-JNK signaling is a novel molecular target for modulating memory.