Related Experiment Video

Updated: Feb 13, 2026

Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib
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Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib

Published on: June 26, 2019

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Afatinib in advanced NSCLC: a profile of its use

Emma D Deeks1, Gillian M Keating1

  • 1Springer, Private Bag 65901, Mairangi Bay, 0754 Auckland, New Zealand.

Drugs & Therapy Perspectives : for Rational Drug Selection and Use
|March 16, 2018
PubMed

Insights

Afatinib is an effective treatment for advanced non-small cell lung cancer (NSCLC) with EGFR mutations, improving progression-free survival. It also benefits squamous NSCLC patients progressing after chemotherapy.

Area of Science:

  • Oncology
  • Pharmacology
  • Medical Oncology

Background:

  • Afatinib is an irreversible ErbB family tyrosine kinase inhibitor.
  • It is approved for advanced non-small cell lung cancer (NSCLC) with specific epidermal growth factor receptor (EGFR) mutations and for squamous NSCLC post-chemotherapy.

Purpose of the Study:

  • To evaluate afatinib's efficacy and safety in advanced NSCLC.
  • Compare afatinib with gefitinib and chemotherapy in the first-line setting for EGFR-mutated NSCLC.
  • Assess afatinib versus erlotinib in the second-line setting for advanced squamous NSCLC.

Main Methods:

  • Clinical trials comparing afatinib to gefitinib and platinum-based chemotherapy.
  • Second-line treatment comparison of afatinib versus erlotinib.
  • Analysis of progression-free survival (PFS), time to treatment failure (TTF), and overall survival (OS).

Main Results:

  • Afatinib demonstrated prolonged PFS and TTF compared to gefitinib in first-line EGFR-mutated NSCLC, without improving overall survival (OS).
  • In the first-line setting, afatinib improved PFS versus chemotherapy, with a notable OS benefit in patients with exon 19 deletions.
  • As second-line therapy for squamous NSCLC, afatinib showed improved PFS and OS compared to erlotinib, irrespective of EGFR mutation status.

Conclusions:

  • Afatinib is a valuable first-line option for EGFR-mutated NSCLC and an effective second-line treatment for advanced squamous NSCLC.
  • Afatinib offers manageable tolerability and demonstrates clinical benefits in specific NSCLC patient populations.
  • The drug's efficacy varies depending on the NSCLC subtype, mutation status, and treatment line.

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