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Updated: Feb 13, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Transcranial diffuse optical assessment of the microvascular reperfusion after thrombolysis for acute ischemic stroke
Raquel Delgado-Mederos1, Clara Gregori-Pla2, Peyman Zirak2
1Department of Neurology, Hospital de la Santa Creu i Sant Pau, C. Sant Antoni M Claret 167, 08025, Barcelona, Spain.
Abstract:
In this pilot study, we have evaluated bedside diffuse optical monitoring combining diffuse correlation spectroscopy and near-infrared diffuse optical spectroscopy to assess the effect of thrombolysis with an intravenous recombinant tissue plasminogen activator (rtPA) on cerebral hemodynamics in an acute ischemic stroke. Frontal lobes of five patients with an acute middle cerebral artery occlusion were measured bilaterally during rtPA treatment. Both ipsilesional and contralesional hemispheres showed significant increases in cerebral blood flow, total hemoglobin concentration and oxy-hemoglobin concentration during the first 2.5 hours after rtPA bolus. The increases were faster and higher in the ipsilesional hemisphere. The results show that bedside optical monitoring can detect the effect of reperfusion therapy for ischemic stroke in real-time.
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