Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Trigonometric Identities II01:28

Trigonometric Identities II

435
Double-angle and half-angle trigonometric identities are derived from the fundamental sum and difference formulas and serve as essential tools for simplifying expressions, solving equations, and evaluating integrals. These identities reduce the complexity of trigonometric functions by relating functions of a multiple or fractional angle to functions of a single angle. Their applications extend across mathematics, physics, and engineering, particularly in Fourier analysis, wave mechanics, and...
435
Personal Identity01:25

Personal Identity

467
Personal identity is the deeply felt sense of self that individuals cultivate over time, intricately woven from intrinsic qualities they consider essential to their existence—qualities such as morality, intelligence, and friendliness. These attributes serve as vital internal benchmarks, guiding individuals in evaluating whether their actions resonate with their true selves.When personal identity takes center stage in one's life, individuals often emphasize their distinctiveness,...
467
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

16.6K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.6K
Social Identity01:29

Social Identity

359
Social identity constitutes a significant aspect of an individual’s self-concept, shaped by membership in various social groups, including gender, nationality, ethnicity, sexual orientation, and political affiliation. Individuals associate specific traits with particular social groups, leading to internalization of these traits. For example, musicians are often perceived as creative, while women are frequently associated with nurturing tendencies. Once individuals identify with a...
359
Trigonometric Identities I01:27

Trigonometric Identities I

254
Trigonometric identities are equations that relate trigonometric functions and hold for all angles within their domains. A fundamental identity among these is the Pythagorean identity, which arises directly from the geometry of the unit circle. For any angle θ, a point on the unit circle has coordinates (cos⁡ θ, sin ⁡θ), and since the radius of the circle is one, the Pythagorean Theorem gives:This identity serves as the basis for deriving additional identities.
254
Marcia's Theory of Identity Status01:26

Marcia's Theory of Identity Status

1.7K
James Marcia's identity status model provides a framework for understanding how adolescents navigate identity formation through varying degrees of exploration and commitment. Marcia's model builds on Erik Erikson's theories of psychosocial development, focusing specifically on how adolescents reconcile individual aspirations with societal expectations. His model describes identity formation as a dynamic process where adolescents move between different states depending on their level...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Succinate receptor 1 restricts hematopoiesis and prevents acute myeloid leukemia progression.

Nature communications·2026
Same author

HDL-associated phosphatidylserine blunts myeloid activation and protects from atherosclerosis.

bioRxiv : the preprint server for biology·2025
Same author

Bone marrow sympathetic neuropathy is a hallmark of hematopoietic malignancies and it involves severe ultrastructural damage.

Experimental hematology & oncology·2025
Same author

Author Correction: Endogenous IL-1 receptor antagonist restricts healthy and malignant myeloproliferation.

Nature communications·2023
Same author

Endogenous IL-1 receptor antagonist restricts healthy and malignant myeloproliferation.

Nature communications·2023
Same author

Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells.

eLife·2022

Related Experiment Video

Updated: Feb 13, 2026

A Quantitative Assay for Insulin-expressing Colony-forming Progenitors
14:39

A Quantitative Assay for Insulin-expressing Colony-forming Progenitors

Published on: November 28, 2011

14.0K

Nestin-expressing progenitor cells: function, identity and therapeutic implications.

Aurora Bernal1, Lorena Arranz2,3,4

  • 1Stem Cell Aging and Cancer Research Group, Department of Medical Biology, Faculty of Health Sciences, UiT, The Arctic University of Norway, MH Building Level 6, 9019, Tromsø, Norway.

Cellular and Molecular Life Sciences : CMLS
|March 16, 2018
PubMed
Summary

Nestin, a protein in neural stem cells, also plays roles in other tissues like bone marrow. Further research into Nestin+ cells could reveal new therapeutic targets for various diseases.

Keywords:
Central and peripheral nervous systemsHematological malignanciesHematopoietic stem cell nicheMesenchymal stromal cellsMouse modelsNestinNeural stem and progenitor cellsNeurodegenerative diseases

More Related Videos

Identifying Cell Surface Markers of Primary Neural Stem and Progenitor Cells by Metabolic Labeling of Sialoglycan
11:39

Identifying Cell Surface Markers of Primary Neural Stem and Progenitor Cells by Metabolic Labeling of Sialoglycan

Published on: September 7, 2019

5.7K
Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells
12:04

Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells

Published on: March 10, 2023

4.9K

Related Experiment Videos

Last Updated: Feb 13, 2026

A Quantitative Assay for Insulin-expressing Colony-forming Progenitors
14:39

A Quantitative Assay for Insulin-expressing Colony-forming Progenitors

Published on: November 28, 2011

14.0K
Identifying Cell Surface Markers of Primary Neural Stem and Progenitor Cells by Metabolic Labeling of Sialoglycan
11:39

Identifying Cell Surface Markers of Primary Neural Stem and Progenitor Cells by Metabolic Labeling of Sialoglycan

Published on: September 7, 2019

5.7K
Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells
12:04

Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells

Published on: March 10, 2023

4.9K

Area of Science:

  • Biochemistry
  • Cell Biology
  • Regenerative Medicine

Background:

  • Nestin is a cytoskeletal intermediate filament protein primarily identified in neural stem cells.
  • Emerging evidence indicates Nestin expression in progenitor cells across multiple tissues, notably bone marrow.
  • Nestin's role extends beyond the nervous system, suggesting broader stem cell regulatory functions.

Purpose of the Study:

  • To review the current understanding of Nestin's involvement in fundamental stem cell processes.
  • To explore the function and characteristics of Nestin-expressing cells in the nervous system and bone marrow.
  • To discuss the therapeutic potential of Nestin+ cells in preclinical disease models.

Main Methods:

  • Literature review of in vivo and human studies on Nestin expression and function.
  • Analysis of data concerning Nestin's role in stem cell self-renewal, differentiation, and migration.
  • Examination of in vivo models for studying Nestin+ cells and their progeny.

Main Results:

  • Nestin is crucial for self-renewal, proliferation, differentiation, and migration of stem cells.
  • Nestin+ cells exhibit progenitor and regulatory functions in both neural and non-neural tissues, including bone marrow.
  • Preclinical studies highlight the mechanistic role and therapeutic promise of Nestin+ cells in disease models.

Conclusions:

  • Nestin is a key protein involved in essential stem cell functions across various tissues.
  • Nestin+ cells in the nervous system and bone marrow possess significant progenitor and regulatory capabilities.
  • Advancements in in vivo models and detection methods are crucial for elucidating Nestin+ cell biology and therapeutic applications.