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A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
Incidence of renal artery stenosis in a population having cardiac catheterization
Insights
Screening for renal artery stenosis during cardiac catheterization is not routinely justified. Significant renovascular hypertension is rare, even in hypertensive patients undergoing the procedure.
Area of Science:
- Cardiology
- Nephrology
- Vascular Medicine
Background:
- Renovascular hypertension is a less common cause of hypertension.
- Identifying renal artery stenosis is crucial for appropriate patient management.
Purpose of the Study:
- To determine the frequency of renal artery stenosis and renovascular hypertension in patients undergoing cardiac catheterization.
- To evaluate the utility of routine screening for renal artery stenosis in this population.
Main Methods:
- 102 consecutive patients undergoing cardiac catheterization were screened for renal artery stenosis.
- Renal artery stenosis severity was assessed.
- Renal vein renin levels were measured in select patients to determine lateralization.
Main Results:
- 64% of patients were hypertensive.
- 13.7% of the total population had renal artery stenosis.
- Only 5 patients had >50% arterial lumen narrowing.
- Only 4 of these 5 patients had lateralizing renins, indicating significant renovascular hypertension.
Conclusions:
- The low prevalence of significant renovascular hypertension does not support routine screening during cardiac catheterization.
- Screening may be beneficial for hypertensive patients undergoing the procedure.
- Further research is warranted to define optimal screening strategies.
Abstract:
Patients with renovascular hypertension comprise only a small percentage of those with hypertension. In our study 102 consecutive patients who had cardiac catheterization were screened at the time of the procedure for renal artery stenosis. Only 65 (64%) of the 102 patients were hypertensive, and 14 of the total population (13.7%) had renal artery stenosis. Of these 14 patients, only five had more than 50% narrowing of the arterial lumen. By renal vein renin determination, only four of the five patients with significant renal artery stenosis had lateralizing renins. The frequency of significant renovascular hypertension does not justify the routine search for this problem during catheterization procedures, though it may be worthwhile if the patients are hypertensive. This area deserves further evaluation.
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