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Updated: Feb 13, 2026

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis
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Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis

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Restriction spectrum imaging of white matter and its relation to neurological disability in multiple sclerosis

Piotr Sowa1, Hanne F Harbo2, Nathan S White3

  • 1Division of Radiology & Nuclear Medicine, Oslo University Hospital, Oslo, Norway/Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|March 16, 2018
PubMed
Abstract

Insights

Restriction spectrum imaging (RSI) reveals that neurite density in normal-appearing white matter strongly correlates with multiple sclerosis (MS) disability. These findings suggest RSI parameters may help understand MS progression and monitor disease.

Area of Science:

  • Neurology
  • Radiology
  • Biomedical Engineering

Background:

  • Restriction spectrum imaging (RSI) is an advanced magnetic resonance imaging diffusion technique.
  • The application of RSI in multiple sclerosis (MS) has not been previously explored.

Purpose of the Study:

  • To investigate the relationship between RSI-derived metrics and neurological disability in MS patients.

Main Methods:

  • Seventy-seven relapsing-remitting MS patients underwent RSI scanning.
  • RSI parameters were analyzed in white matter lesions (WML) and normal-appearing white matter (NAWM).
  • Patients were stratified by Expanded Disability Status Scale (EDSS) to assess disability correlations.

Main Results:

  • Significant differences in all RSI parameters were observed between WML and NAWM.
  • Slow apparent diffusion coefficient (sADC) in WML showed the most significant variation across disability groups.
  • Neurite density (ND) in NAWM demonstrated the strongest correlation with patient disability (ϱ = -0.39, p < 0.001).

Conclusions:

  • Neurological disability in MS is influenced by processes occurring outside of visible lesions.
  • RSI-derived parameters show potential for elucidating the clinico-radiological paradox in MS.
  • RSI may offer improved methods for monitoring MS disease progression.
Keywords:
Magnetic resonance imagingmultiple sclerosisneurite densityneurological disabilityrestriction spectrum imaging

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