Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

1.6K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.6K
Antibiotic Selection00:57

Antibiotic Selection

60.2K
Overview
60.2K
In Vitro Drug Release Testing: Overview, Development and Validation01:10

In Vitro Drug Release Testing: Overview, Development and Validation

367
In vitro dissolution and drug release tests assess how quickly and how much of a drug is released from its dosage form into an aqueous medium under standardized laboratory conditions. These tests are essential tools in pharmaceutical development and quality assurance, offering insight into the drug's performance before clinical use.During formulation development, dissolution testing identifies incomplete or inconsistent drug release issues. It also supports decisions on selecting the optimal...
367
Energy-releasing Steps of Glycolysis01:28

Energy-releasing Steps of Glycolysis

147.2K
Glycolysis is divided into two phases based on whether energy is utilized or released. While the first phase consumes ATP, the second phase produces energy in the form of ATP and NADH. The energy is released over a sequence of reactions that turns G3P into pyruvate. The energy-releasing phase—steps 6-10 of glycolysis—occurs twice, once for each of the two 3-carbon sugars produced during steps 1-5 of the first phase.
The first energy-releasing step—the 6th step of glycolysis...
147.2K
Sustainable Development01:43

Sustainable Development

15.2K
As the human population continues to grow and use resources, we must be mindful of our planet’s natural limits. Sustainable development provides a pathway to maintain and improve human life now while also ensuring that future generations will have the resources that they need. The long-term success of sustainability efforts rests on understanding the interplay between human actions and ecological systems.
15.2K
Modified-Release Drug Delivery Systems: Drug Release Characteristics01:22

Modified-Release Drug Delivery Systems: Drug Release Characteristics

1
Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...
1

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Shikonin-loaded porous graphdiyne nanofilm on titanium surface for enhanced antibacterial activity and osseointegration.

Bioactive materials·2026
Same author

Salt-triggered electroactive dressing with controlled drug release for enhanced healing of exudative wounds.

Biomaterials·2025
Same author

Missing teeth, mortality, and hospitalization: A population-based cohort analysis from the Canadian Health Measures Survey and linked databases.

Health reports·2025
Same author

Amyloid-like Protein-Metal Sulfide Nanocoatings for Synergistic Photothermal and Antibacterial Implant Surface Protection.

ACS nano·2025
Same author

Corrigendum to "Copper tannate nanosheets-embedded multifunctional coating for antifouling and photothermal bactericidal application" [Colloids Surf. B: Biointerfaces 245 (2025) 114208].

Colloids and surfaces. B, Biointerfaces·2025
Same author

Correction to "Biomimetic Engineering of Robust Gradient Antibacterial Coatings Using Hollow Nanoframes of Prussian Blue Analogues".

Advanced materials (Deerfield Beach, Fla.)·2025

Related Experiment Video

Updated: Feb 13, 2026

Antibiotic Dereplication Using the Antibiotic Resistance Platform
10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

11.7K

Recent Developments in Controlled Release of Antibiotics.

Ling Gui Ning1,2, En-Tang Kang3, Yun Bing Wang4

  • 1Institute for Clean Energy and Advanced Materials, Faculty of Materials and Energy, Southwest University, Chongqing, 400715, China.

Current Pharmaceutical Design
|March 16, 2018
PubMed
Summary

Antibiotic drug delivery systems are needed to combat implant infections. This review explores carrier platforms for controlled antibiotic release and their effectiveness against bacteria.

Keywords:
Antibioticsbacterial infectioncontrolled release systemsdrug carrier systemsdrug resistanceimplants.

More Related Videos

Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules
11:13

Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules

Published on: August 19, 2015

8.7K
Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers
11:53

Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers

Published on: July 21, 2017

7.7K

Related Experiment Videos

Last Updated: Feb 13, 2026

Antibiotic Dereplication Using the Antibiotic Resistance Platform
10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

11.7K
Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules
11:13

Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules

Published on: August 19, 2015

8.7K
Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers
11:53

Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers

Published on: July 21, 2017

7.7K

Area of Science:

  • Biomaterials Science
  • Infectious Diseases
  • Drug Delivery

Background:

  • Conventional antibiotic administration (oral, injection) has limitations including host toxicity, reduced efficacy, and antimicrobial resistance.
  • Implant-associated infections necessitate continuous, localized antibiotic delivery for effective prevention and treatment.
  • A significant need exists for advanced drug carrier systems capable of controlled antibiotic release over specific durations.

Purpose of the Study:

  • To review various carrier platforms developed for antibiotic loading.
  • To analyze the drug release characteristics of these antibiotic carriers.
  • To evaluate the in vitro and in vivo antibacterial efficacy of antibiotic-loaded carriers.

Main Methods:

  • Literature review of scientific publications on antibiotic carrier systems.
  • Analysis of studies detailing drug release kinetics from different carrier platforms.
  • Examination of in vitro and in vivo studies assessing the antibacterial performance of these systems.

Main Results:

  • Various carrier platforms (e.g., nanoparticles, hydrogels, microspheres) have been investigated for antibiotic delivery.
  • These platforms demonstrate diverse drug release profiles, ranging from burst release to sustained release.
  • Antibiotic carriers show promising in vitro and in vivo antibacterial activity against relevant pathogens.

Conclusions:

  • Drug carrier systems offer a viable strategy for localized and controlled antibiotic delivery, overcoming limitations of traditional methods.
  • The choice of carrier platform influences antibiotic release kinetics and antibacterial efficacy.
  • Further development of these systems is crucial for managing implant-associated infections and combating antibiotic resistance.