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Neurocryptococcosis in acquired immunodeficiency syndrome
Ims Sawhney1, G Singh1, S Sehgal1
1Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh - 160012, India.
Neurology India
|March 16, 2018
Summary
This study details two cases of Neurocryptococcosis in patients with Acquired Immunodeficiency Syndrome (AIDS). It highlights distinct clinical signs, diagnostic findings, and therapeutic adjustments for this opportunistic infection in immunocompromised individuals.
Area of Science:
- Infectious Diseases
- Neurology
- Immunology
Background:
- Neurocryptococcosis is a serious opportunistic infection in patients with Acquired Immunodeficiency Syndrome (AIDS).
- Disseminated cryptococcosis can present with varied and sometimes subtle clinical manifestations.
Purpose of the Study:
- To describe two distinct cases of Neurocryptococcosis in AIDS patients.
- To discuss the unique clinical presentations, diagnostic findings, and therapeutic strategies for Neurocryptococcosis in the context of AIDS.
Main Methods:
- Case report analysis of two patients diagnosed with Neurocryptococcosis and AIDS.
- Review of clinical manifestations, laboratory investigations, and treatment modifications.
Main Results:
- Patient 1 presented with generalized lymphadenopathy, hepatosplenomegaly, and increased intracranial pressure.
- Patient 2 exhibited prolonged fever and hepatosplenomegaly, indicative of disseminated cryptococcosis.
- Both cases demonstrated the challenges in diagnosing and managing Neurocryptococcosis in advanced HIV infection.
Conclusions:
- Neurocryptococcosis in AIDS patients requires vigilant clinical suspicion due to diverse presentations.
- Early recognition of investigative abnormalities and prompt therapeutic adjustments are crucial for improved outcomes.
- Understanding these distinct manifestations aids in timely diagnosis and effective management of cryptococcal infections in immunocompromised individuals.
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