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Area of Science:

  • Neuro-oncology
  • Neurosurgery
  • Pathology

Background:

  • Multifocal synchronous gliomas are rare, particularly when not associated with phakomatosis.
  • Understanding the spread patterns of these tumors is crucial for effective treatment.

Purpose of the Study:

  • To report two rare cases of multifocal synchronous gliomas.
  • To discuss the potential modes of spread for these lesions.
  • To propose a management guideline for such cases.

Main Methods:

  • Case report analysis.
  • Literature review on glioma spread.
  • Clinical guideline development based on case findings.

Main Results:

  • Two distinct cases of multifocal synchronous gliomas were identified and analyzed.
  • Potential routes of dissemination, including leptomeningeal and intraparenchymal spread, were considered.
  • A proposed management guideline was formulated.

Conclusions:

  • Multifocal synchronous gliomas necessitate careful consideration of their origin and spread.
  • A structured approach and guideline are beneficial for managing these uncommon presentations.
  • Further research into the pathogenesis and treatment of these lesions is warranted.