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Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting
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Y1 receptor ligand-based nanomicelle as a novel nanoprobe for glioma-targeted imaging and therapy

Juan Li1, Yang Du, Zhenqi Jiang

  • 1CAS Key Laboratory of Magnetic Materials and Devices, Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, and Division of Functional Materials and Nanodevices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China. aiguo@nimte.ac.cn.

Nanoscale
|March 16, 2018
PubMed

Insights

Researchers developed a novel nanomicelle delivery system targeting Neuropeptide Y Y1 receptors (Y1Rs) for glioma. This system enhances drug delivery across the blood-brain barrier, improving therapeutic efficacy and survival rates in glioma treatment.

Area of Science:

  • Neuroscience
  • Oncology
  • Nanotechnology
  • Pharmacology

Background:

  • Glioma heterogeneity poses challenges for targeted imaging and therapy.
  • Neuropeptide Y Y1 receptors (Y1Rs) are overexpressed in brain tumors, presenting a potential therapeutic target.

Purpose of the Study:

  • To investigate the potential of a novel Y1R ligand, [Asn6, Pro34] NPY (AP-NPY), for targeted glioma therapy.
  • To evaluate AP-NPY-modified nanomicelles for enhanced drug delivery across the blood-brain barrier (BBB).

Main Methods:

  • In vivo fluorescent imaging to assess BBB penetration and glioma targeting.
  • Development of doxorubicin-loaded nanomicelles modified with AP-NPY.
  • Evaluation of nanomicelle stability and drug release in different microenvironments.
  • Assessment of therapeutic efficacy and survival rates in glioma models.

Main Results:

  • AP-NPY facilitated nanomicelle circumvention of the BBB, specifically targeting glioma.
  • AP-NPY modified nanomicelles showed controlled doxorubicin release in the acidic tumor microenvironment.
  • Targeted delivery improved doxorubicin's therapeutic efficacy, leading to prolonged survival.

Conclusions:

  • Y1R is a viable target for glioma therapy.
  • AP-NPY is a promising ligand for enhancing BBB permeability and glioma targeting.
  • AP-NPY-modified nanomicelles represent a novel delivery system for glioma diagnosis and treatment.

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