Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Analysis of alloantigen-specific suppressor T cells.

I Aoki, N Ishii, M Minami

    Transplantation
    |June 1, 1987
    PubMed
    Summary

    This study identifies two types of suppressor T cells involved in immune responses. These cells, differing in function and genetic control, suggest a shared mechanism between allospecific and hapten-specific suppressor T cells.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Biphasic aspect of sexually dimorphic ontogenetic trajectory of gyrification in the ferret cerebral cortex.

    Neuroscience·2017
    Same author

    MRI of cerebral micro-vascular flow patterns: A multi-direction diffusion-weighted ASL approach.

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2016
    Same author

    Feeding ecology of two lanternfishes Diaphus garmani and Diaphus chrysorhynchus.

    Journal of fish biology·2013
    Same author

    NEDDylation controls the target specificity of E2F1 and apoptosis induction.

    Oncogene·2012
    Same author

    Repeated longitudinal in vivo imaging of neuro-glio-vascular unit at the peripheral boundary of ischemia in mouse cerebral cortex.

    Neuroscience·2012
    Same author

    Simultaneous evaluation of long-lasting knee synovitis in patients undergoing arthroplasty by power Doppler ultrasonography and contrast-enhanced MRI in comparison with histopathology.

    Clinical and experimental rheumatology·2012

    Area of Science:

    • Immunology
    • Cellular immunology
    • T cell subsets

    Background:

    • Delayed-type hypersensitivity (DTH) responses are crucial immune mechanisms.
    • Suppressor T cells play a critical role in regulating immune responses.
    • Understanding T cell subsets involved in immune regulation is essential.

    Purpose of the Study:

    • To investigate the distinct subsets of alloantigen-specific suppressor T cells.
    • To characterize the functional and genetic properties of these suppressor T cell subsets.
    • To compare the mechanisms of action between allospecific and hapten-specific suppressor T cells.

    Main Methods:

    • Intravenous administration of allogeneic spleen cells.
    • Analysis of T cell subsets based on Lyt2 expression.

    Related Experiment Videos

  • Assessment of H-2 region gene control on T cell activity.
  • Investigation of antigen-dependent bystander suppression.
  • Evaluation of cyclophosphamide-sensitive targets in suppression.

    • Main Results:

    • Two distinct subsets of alloantigen-specific suppressor T cells were induced: induction phase and effector phase.
    • Induction phase suppressor T cells are Lyt2- and H-2 non-restricted.
    • Effector phase suppressor T cells are Lyt2+ and H-2 restricted, mediating bystander suppression.
    • Effector phase suppression involves cyclophosphamide-sensitive targets.

    Conclusions:

    • Allogeneic spleen cell administration induces functionally and genetically distinct suppressor T cell subsets.
    • Effector phase suppressor T cells exhibit antigen-dependent bystander suppression.
    • The mechanisms of action for allospecific and hapten-specific suppressor T cells appear similar.